Aluminum,[1-propen-1-olato(3-)-kC3,kO1]- (9CI)

Base Information

• Chemical Name: Aluminum,[1-propen-1-olato(3-)-kC3,kO1]- (9CI)
• CAS No.: 287-72-9
• Molecular Formula: C3H3 Al O

Synonyms:1,2-Oxaluminole(8CI); Aluminum, [1-propen-1-olato(3-)-C3,O1]-; 1-Propen-1-ol, aluminum complex

Chemical Property of Aluminum,[1-propen-1-olato(3-)-kC3,kO1]- (9CI)

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Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel"

10.1039/c7ob02828h

The study was guided by X-ray structural biology data of HIV-1 RT/NNRTIs complexes and molecular modeling, leading to the design and synthesis of a new series of DAPYs. The purpose was to further investigate the chemical space of the less explored "hydrophobic channel" and to develop NNRTIs with improved resistance profiles. The conclusions drawn from the research indicate that most of the synthesized DAPYs were active against HIV-1 wild-type with low nanomolar EC50 values and displayed reduced cytotoxicity compared to existing drugs like etravirine and rilpivirine. Notably, compounds Z10 and Z13 showed equivalent potency against HIV-1 wild-type as reference drugs efavirenz and etravirine.

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