(2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide

Base Information

• Chemical Name: (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide
• CAS No.: 53984-26-2
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.2575
• Mol file: 53984-26-2.mol

Synonyms:2-amino-N-(2,6-dimethylphenyl)propanamide;(R)-2-Amino-N-(2,6-dimethyl-phenyl)-propionamide;(R)-tocainide;

Chemical Property of (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide

Chemical Property:

• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 153.5°C
• PSA: 55.12000
• Density: 1.094g/cm³
• LogP: 2.36240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide

There total 4 articles about (2R)-N-(2,6-Dimethylphenyl)-2-aminopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(+)-(R)-N2-(tert-butoxycarbonyl)-N1-(2,6-dimethylphenyl)alaninamide (151416-30-7) → (-)-Tocainide (53984-26-2,76213-25-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 25 ℃; for 24h;

DOI:10.1002/adsc.201700134

Reference yield:

tocainide (41708-72-9,76213-25-7) → (+)-Tocainide (53984-75-1,76213-25-7) + (-)-Tocainide (53984-26-2,76213-25-7)

Guidance literature:

With sulfuric acid; In methanol; water; at 20 ℃; Resolution of racemate;

DOI:10.5012/bkcs.2010.31.03.678

Reference yield:

N-tert-butyl-N'-(2,6-dimethylphenyl)-S-phenylisothiourea → (-)-Tocainide (53984-26-2,76213-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iron(III)-acetylacetonate / isopropyl alcohol / 72 h / 83 °C / Sealed tube

2: hydrogenchloride / ethyl acetate; 1,4-dioxane / 24 h / 25 °C

With hydrogenchloride; iron(III)-acetylacetonate; In 1,4-dioxane; ethyl acetate; isopropyl alcohol;

DOI:10.1002/adsc.201700134

upstream raw materials:

tocainide

(+)-(R)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)alaninamide