Technology Process of Dephostatin
There total 10 articles about Dephostatin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen fluoride; sodium fluoride;
In
tetrahydrofuran;
at 25 ℃;
for 24h;
DOI:10.1039/c39940000437
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 78 percent / nitrosonium tetrafluoroborate, Et3N / diethyl ether / Ambient temperature
2: 62 percent / TBAF / tetrahydrofuran / 0 °C
With
tetrabutyl ammonium fluoride; nitrosonium tetrafluoroborate; triethylamine;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4039(94)88253-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: imidazole / dimethylformamide / Ambient temperature
2: 83 percent / NaBH4, nickel(II) chloride*6 H2O / methanol / Ambient temperature
3: 92 percent / formic acid / 0 °C
4: 95 percent / borane-THF / tetrahydrofuran / Ambient temperature
5: 78 percent / nitrosonium tetrafluoroborate, Et3N / diethyl ether / Ambient temperature
6: 62 percent / TBAF / tetrahydrofuran / 0 °C
With
1H-imidazole; sodium tetrahydroborate; borane-THF; tetrabutyl ammonium fluoride; nitrosonium tetrafluoroborate; triethylamine; nickel dichloride;
In
tetrahydrofuran; methanol; formic acid; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(94)88253-3
