(5E)-3-[4-({(E)-[(E)-[2-(4-chlorophenyl)hydrazinyl](6-oxocyclohexa-2,4-dien-1-ylidene)methyl]diazenyl}carbonyl)phenyl]-5-(1H-indol-3-ylmethylidene)-2-methyl-3,5-dihydro-4H-imidazol-4-one

Base Information

• Chemical Name: (5E)-3-[4-({(E)-[(E)-[2-(4-chlorophenyl)hydrazinyl](6-oxocyclohexa-2,4-dien-1-ylidene)methyl]diazenyl}carbonyl)phenyl]-5-(1H-indol-3-ylmethylidene)-2-methyl-3,5-dihydro-4H-imidazol-4-one
• CAS No.: 134248-52-5
• Molecular Formula: C₃₃H₂₄ClN₇O₃
• Molecular Weight: 602.052
• Mol file: 134248-52-5.mol

Synonyms:

Chemical Property of (5E)-3-[4-({(E)-[(E)-[2-(4-chlorophenyl)hydrazinyl](6-oxocyclohexa-2,4-dien-1-ylidene)methyl]diazenyl}carbonyl)phenyl]-5-(1H-indol-3-ylmethylidene)-2-methyl-3,5-dihydro-4H-imidazol-4-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 751.6°Cat760mmHg
• Flash Point: 408.3°C
• Density: 1.39g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5E)-3-[4-({(E)-[(E)-[2-(4-chlorophenyl)hydrazinyl](6-oxocyclohexa-2,4-dien-1-ylidene)methyl]diazenyl}carbonyl)phenyl]-5-(1H-indol-3-ylmethylidene)-2-methyl-3,5-dihydro-4H-imidazol-4-one

There total 5 articles about (5E)-3-[4-({(E)-[(E)-[2-(4-chlorophenyl)hydrazinyl](6-oxocyclohexa-2,4-dien-1-ylidene)methyl]diazenyl}carbonyl)phenyl]-5-(1H-indol-3-ylmethylidene)-2-methyl-3,5-dihydro-4H-imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1'H-indol-3'-ylmethylene)-2-methyl-5(4H)oxazolone (54753-57-0,70082-68-7,70082-69-8) → 4-{4-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-benzoic acid [1-(4-chloro-phenylazo)-1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (134248-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / 0.33 h / 140 °C

2: 75 percent / 99percent N₂H₄*H₂O / ethanol / 8 h / Heating

3: 62 percent / glacial AcOH / ethanol / 5 h / Heating

4: 1) glacial AcOH, HCl, NaNO₂ 2) pyridine / 1) water, 0-5 deg C 2) r.t., overnight

With pyridine; hydrogenchloride; hydrazine hydrate; acetic acid; sodium nitrite; In ethanol;

Reference yield:

Methyl 4-<4,5-dihydro-4-(1H-indol-3-ylmethylene)-2-methyl-5-oxo-1H-imidazol-1-yl>benzoate (134248-29-6) → 4-{4-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-benzoic acid [1-(4-chloro-phenylazo)-1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (134248-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / 99percent N₂H₄*H₂O / ethanol / 8 h / Heating

2: 62 percent / glacial AcOH / ethanol / 5 h / Heating

3: 1) glacial AcOH, HCl, NaNO₂ 2) pyridine / 1) water, 0-5 deg C 2) r.t., overnight

With pyridine; hydrogenchloride; hydrazine hydrate; acetic acid; sodium nitrite; In ethanol;

Reference yield:

4-<4,5-Dihydro-4-(1H-indol-3-ylmethylene)-2-methyl-5-oxo-1H-imidazol-1-yl>benzoic acid hydrazide (134248-33-2) → 4-{4-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-benzoic acid [1-(4-chloro-phenylazo)-1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide (134248-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / glacial AcOH / ethanol / 5 h / Heating

2: 1) glacial AcOH, HCl, NaNO₂ 2) pyridine / 1) water, 0-5 deg C 2) r.t., overnight

With pyridine; hydrogenchloride; acetic acid; sodium nitrite; In ethanol;

upstream raw materials:

4-chloro-aniline

4-{4-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-benzoic acid [1-(2-hydroxy-phenyl)-meth-(Z)-ylidene]-hydrazide

4-(1'H-indol-3'-ylmethylene)-2-methyl-5(4H)oxazolone

Methyl 4-<4,5-dihydro-4-(1H-indol-3-ylmethylene)-2-methyl-5-oxo-1H-imidazol-1-yl>benzoate