Dicetylamine

Base Information

• Chemical Name: Dicetylamine
• CAS No.: 16724-63-3
• Molecular Formula: C32H67 N
• Molecular Weight: 465.891
• Hs Code.: 2921199090
• European Community (EC) Number: 270-417-2,240-779-6,268-222-2
• UNII: 05Y5G77L4R
• DSSTox Substance ID: DTXSID60867439
• Nikkaji Number: J236.837D
• Wikidata: Q27236149
• Mol file: 16724-63-3.mol

Synonyms:Dihexadecylamine;Dicetylamine;16724-63-3;1-Hexadecanamine, N-hexadecyl-;N-hexadecylhexadecan-1-amine;N-Hexadecyl-1-hexadecanamine;UNII-05Y5G77L4R;68037-98-9;05Y5G77L4R;EINECS 240-779-6;EINECS 268-222-2;EINECS 270-417-2;68439-74-7;di(hexadecyl)amine;n,n-dihexadecylamine;dipalmitylamine;di-n-hexadecylamine;SCHEMBL64941;ARMEEN 2-16;C32H67N;DTXSID60867439;C32-H67-N;Q27236149

Chemical Property of Dicetylamine

Chemical Property:

• Vapor Pressure: 1.36E-11mmHg at 25°C
• Melting Point: 67.03°C
• Refractive Index: 1.4783 (estimate)
• Boiling Point: 536.7°Cat760mmHg
• PKA: 10.84±0.19(Predicted)
• Flash Point: 185°C
• PSA: 12.03000
• Density: 0.823g/cm³
• LogP: 11.92950
• XLogP3: 15.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 30
• Exact Mass: 465.527351141
• Heavy Atom Count: 33
• Complexity: 284

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: UVCB
• Canonical SMILES: CCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCC

Technology Process of Dicetylamine

There total 26 articles about Dicetylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

hexadecylamine (143-27-1) → dihexadecylamine (16724-63-3)

Guidance literature:

With Co₂Rh₂/C; In toluene; at 180 ℃; for 18h; under 760.051 Torr; Autoclave; Inert atmosphere;

DOI:10.1002/adsc.201701522

Reference yield: 95.0%

hexadecylamine (143-27-1) + 1-Hexadecanol (36653-82-4,124-29-8) → dihexadecylamine (16724-63-3)

Guidance literature:

With platinum-titanium/titanium oxide catalyst; In toluene; at 120 ℃; for 48h; Temperature; Solvent; Reagent/catalyst; Sealed tube;

Reference yield: 76.0%

N,N-Dihexadecyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-74-3) → dihexadecylamine (16724-63-3)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 60 ℃; for 4h;

DOI:10.1016/S0040-4039(98)00990-3

upstream raw materials:

hexadecylamine

1-iodohexadecane

1-Chlorohexadecan

palmitanilide

Downstream raw materials:

trihexadecylamine

α-[N,N-di(n-hexadecyl)amino]-m-toluonitrile

dabcyl dicetylamide

{2-[2-(2-dihexadecylcarbamoylmethoxy-acetylamino)-acetylamino]-acetylamino}-acetic acid benzyl ester

Refernces

• 1、 Habrant, Damien,Peuziat, Pauline,Colombani, Thibault,Dallet, Laurence,Gehin, Johan,Goudeau, Emilie,Evrard, Bérangère,Lambert, Olivier,Haudebourg, Thomas,Pitard, Bruno. "Design of Ionizable Lipids to Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA". . p. 3046 - 3062. Retrieved 2016.
• 2、 Wang, Yanfang,Wang, Beibei,Liao, Han,Song, Xiaojie,Wu, Hao,Wang, Huihui,Shen, Hujun,Ma, Xiaojun,Tan, Mingqian. "Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery". . p. 7291 - 7299. Retrieved 2015.
• 3、 Chung, Hyunho,Han, Seulgi,Chung, Young Keun,Park, Ji Hoon. "Conversion of Primary Amines to Symmetrical Secondary and Tertiary Amines using a Co-Rh Heterobimetallic Nanocatalyst". supporting information. p. 1267 - 1272. Retrieved 2018/02/12.