1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine

Base Information

Chemical Name:1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine
CAS No.:41213-04-1
Molecular Formula:C11H12 Cl F3 N2
Molecular Weight:264.678
Hs Code.:2933599090
European Community (EC) Number:255-267-8
UNII:0BN43QW3C6
DSSTox Substance ID:DTXSID80194138
Nikkaji Number:J320.027B
Wikidata:Q83066894
Mol file:41213-04-1.mol

Synonyms:41213-04-1;1-[4-chloro-3-(trifluoromethyl)phenyl]piperazine;1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine;1-(4-Chloro-3-trifluoromethylphenyl)piperazine;EINECS 255-267-8;0BN43QW3C6;UNII-0BN43QW3C6;1-(3-trifluoromethyl-4-chlorophenyl)piperazine;Piperazine, 1-(4-chloro-3-(trifluoromethyl)phenyl)-;Piperazine,1-[4-chloro-3-(trifluoromethyl)phenyl]-;C11H12ClF3N2;SCHEMBL255333;DTXSID80194138;C11-H12-Cl-F3-N2;GS1709;MFCD00040735;AKOS009096415;AB90989;FS-5421;FT-0607158;4-(4-chloro-3-trifluoromethylphenyl)piperazine;EN300-1932611;1-(4-chloro-3-tri-fluormethyl-phenyl)-piperazine;1-(4-Chloro-3-trifluoromethyl-phenyl)-piperazine;A825469

Suppliers and Price of 1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine
10g
$ 1458.00

Matrix Scientific
1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine
1g
$ 298.00

Matrix Scientific
1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine
5g
$ 810.00

American Custom Chemicals Corporation
1-(4-CHLORO-3-TRIFLUOROMETHYLPHENYL)PIPERAZINE 95.00%
1G
$ 707.04

American Custom Chemicals Corporation
1-(4-CHLORO-3-TRIFLUOROMETHYLPHENYL)PIPERAZINE 95.00%
5G
$ 1093.90

AK Scientific
1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine
2g
$ 522.00

AK Scientific
1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine
5g
$ 927.00

AK Scientific
1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine
500mg
$ 218.00

AK Scientific
1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine
250mg
$ 158.00

AHH
1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine 97%
50g
$ 568.00

Total 14 raw suppliers

Chemical Property of 1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine

Chemical Property:

Vapor Pressure:2.76E-05mmHg at 25°C
Boiling Point:357.3°Cat760mmHg
PKA:8.74±0.10(Predicted)
Flash Point:169.9°C
PSA：15.27000
Density:1.302g/cm³
LogP:3.16220
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:264.0641106
Heavy Atom Count:17
Complexity:254

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=CC(=C(C=C2)Cl)C(F)(F)F

Technology Process of 1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine

There total 4 articles about 1-[4-Chloro-3-(trifluoromethyl)phenyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1121600-01-8
C₁₆H₂₀ClF₃N₂O₂

: 41213-04-1
1-(4-Chloro-3-trifluoromethyl-phenyl)-piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm401752p

Reference yield:

: 110-85-0
piperazine

: 445-01-2
5-bromo-2-chlorobenzotrifluoride

: 41213-04-1
1-(4-Chloro-3-trifluoromethyl-phenyl)-piperazine

Guidance literature:

Reference yield:

: 176976-42-4
(4-chloro-3-(trifluoromethyl)phenyl)boronic acid

: 41213-04-1
1-(4-Chloro-3-trifluoromethyl-phenyl)-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper diacetate / dichloromethane / 0.08 h / 20 °C / Molecular sieve

1.2: 45 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With copper diacetate; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm401752p