4-CHLORO-2-METHYL-6-NITROANILINE

Base Information

• Chemical Name: 4-CHLORO-2-METHYL-6-NITROANILINE
• CAS No.: 62790-50-5
• Molecular Formula: C7H7ClN2O2
• Molecular Weight: 186.598
• Hs Code.: 29214200
• Mol file: 62790-50-5.mol

Synonyms:4-Chloro-2-methyl-6-nitroaniline;4-Chloro-6-nitro-o-toluidine;

Chemical Property of 4-CHLORO-2-METHYL-6-NITROANILINE

Chemical Property:

• Appearance/Colour: orange crystals or needles
• Vapor Pressure: 0.000186mmHg at 25°C
• Melting Point: 126-132 °C
• Refractive Index: 1.627
• Boiling Point: 328.7 °C at 760 mmHg
• PKA: -1.18±0.25(Predicted)
• Flash Point: 152.6 °C
• PSA: 71.84000
• Density: 1.415 g/cm³
• LogP: 3.24320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.3% ^*data from raw suppliers

4-Chloro-2-methyl-6-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-METHYL-6-NITROANILINE

There total 7 articles about 4-CHLORO-2-METHYL-6-NITROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Methyl-6-nitroaniline (570-24-1) → 4-chloro-2-methyl-6-nitrophenylamine (62790-50-5)

Guidance literature:

With N-chloro-succinimide; In methanol; at 60 ℃; for 4h;

DOI:10.1021/jm200128m

Reference yield:

4-chloro-2-methylacetanilide (5202-86-8) → 4-chloro-2-methyl-6-nitrophenylamine (62790-50-5)

Guidance literature:

With sulfuric acid; nitric acid; das Acetylderivat entsteht; es wird durch Kochen mit einem Gemisch von 1 Vol_. rauch.Salzsaeure und 1 Vol_. Alkohol verseift;

Reference yield:

→ 4-chloro-2-methyl-6-nitrophenylamine (62790-50-5) + 4-chloro-2-methyl-5-nitroaniline (34648-99-2)

Guidance literature:

With sulfuric acid; beim Eingiessen der Loesung in Eiswasser;

upstream raw materials:

4-chloro-2-methylacetanilide

2-Methyl-6-nitroaniline

sulfuric acid

N-(2-methylphenyl)acetamide

Downstream raw materials:

3-bromo-N-(4-chloro-2-methyl-6-nitrophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

4-chloro-2-hydroxy-6-methylphenylboronic acid

4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine

2-amino-4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "NICLOSAMIDE ANALOGUES AND THERAPEUTIC USE THEREOF". Paragraph 00157. . Retrieved 2020/02/23.
• 2、 Zehnder, Luke,Bennett, Michael,Meng, Jerry,Huang, Buwen,Ninkovic, Sacha,Wang, Fen,Braganza, John,Tatlock, John,Jewell, Tanya,Zhou, Joe Zhongxiang,Burke, Ben,Wang, Jeff,Maegley, Karen,Mehta, Pramod P.,Yin, Min-Jean,Gajiwala, Ketan S.,Hickey, Michael J.,Yamazaki, Shinji,Smith, Evan,Kang, Ping,Sistla, Anand,Dovalsantos, Elena,Gehring, Michael R.,Kania, Robert,Wythes, Martin,Kung, Pei-Pei. "Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h- pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5, 7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide". supporting information; experimental part. p. 3368 - 3385. Retrieved 2011/06/27.