Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)-

Base Information

Chemical Name:Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)-
CAS No.:72758-47-5
Molecular Formula:C₂₁H₂₅N₇O₅
Molecular Weight:455.473
Hs Code.:
DSSTox Substance ID:DTXSID70223067
Wikidata:Q76155397

Synonyms:BRN 5681427;Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)-;1-(1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranuronoyl)-4-(2-methoxyphenyl)piperazine;72758-47-5;DTXSID70223067;C21H25N7O5;C21-H25-N7-O5;LS-110250

Suppliers and Price of Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 0 raw suppliers

Chemical Property of Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)-

Chemical Property:

Vapor Pressure:8.42E-29mmHg at 25°C
Boiling Point:824.7°Cat760mmHg
Flash Point:452.6°C
Density:1.65g/cm³
XLogP3:-0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:455.19171692
Heavy Atom Count:33
Complexity:696

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1N2CCN(CC2)C(=O)C3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O
Isomeric SMILES:COC1=CC=CC=C1N2CCN(CC2)C(=O)[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O

Technology Process of Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)-

There total 3 articles about Piperazine, 1-(1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranurononyl)-4-(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(3aS,4S,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone

: 72758-47-5
[(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: With formic acid; at 60 - 70 ℃; for 1h;
DOI:10.1021/jm00177a021

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 72758-47-5
[(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / -60 - -40 °C

2: 50percent aq. HCOOH / 1 h / 60 - 70 °C

With formic acid;
DOI:10.1021/jm00177a021

Reference yield:

: 39491-49-1
2',3'-O-isopropylideneadenosine-5'-carbonyl chloride

: 72758-47-5
[(2S,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-[4-(2-methoxy-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / -60 - -40 °C

2: 50percent aq. HCOOH / 1 h / 60 - 70 °C

With formic acid;
DOI:10.1021/jm00177a021