Chemical Property of Aurantio-obtusin
Chemical Property:
- Vapor Pressure:9.8E-15mmHg at 25°C
- Melting Point:265-266 °C
- Refractive Index:1.678
- Boiling Point:594.6 °C at 760 mmHg
- PKA:6.32±0.20(Predicted)
- Flash Point:222.4 °C
- PSA：113.29000
- Density:1.51 g/cm3
- LogP:1.90440
- Storage Temp.:2-8°C
- XLogP3:2.7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:2
- Exact Mass:330.07395278
- Heavy Atom Count:24
- Complexity:521
- Purity/Quality:
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≥98% *data from raw suppliers
Aurantio-obtusin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC2=C(C(=C1O)OC)C(=O)C3=C(C(=C(C=C3C2=O)O)OC)O
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Description
Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD50 = 10 ppm).
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Uses
A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count
