6-EPI PRAVASTATIN, SODIUM SALT

Base Information

• Chemical Name: 6-EPI PRAVASTATIN, SODIUM SALT
• CAS No.: 81176-41-2
• Molecular Formula: C₂₃H₃₅O₇*Na
• Molecular Weight: 446.516
• Hs Code.: 2918195000
• Mol file: 81176-41-2.mol

Synonyms:UNII-K4A67XJY6V;6-epi-Pravastatin sodium salt;6-epi-Pravastatin sodium;

Chemical Property of 6-EPI PRAVASTATIN, SODIUM SALT

Chemical Property:

• PSA: 127.12000
• LogP: 1.10570
• Solubility.: Methanol, Water

Purity/Quality:

98% ^*data from raw suppliers

Pravastatin Related Compound B ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An analogue of Pravastatin, a competitive inhibitor of HMG-CoA reductase.

Technology Process of 6-EPI PRAVASTATIN, SODIUM SALT

There total 8 articles about 6-EPI PRAVASTATIN, SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pravastatin (81093-37-0,81131-74-0,250737-12-3) → pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3)

Guidance literature:

With sodium carbonate; In acetic acid butyl ester; for 3h; Product distribution / selectivity;

Reference yield: 68.4%

→ pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3)

Guidance literature:

Reference yield:

t-octylamine salt of pravastatin → pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3)

Guidance literature:

t-octylamine salt of pravastatin; With sodium hydroxide; In acetic acid butyl ester; water; for 0.166667h; pH=11.3;

In water; pH=8.2;

upstream raw materials:

pravastatin

mevastatin

3β-hydroxy ML-236B methylester

3β-hydroxy ML-236B

Downstream raw materials:

pravastatin

R-195

pravastatin lactone

lactone form of C-6 epimer of pravastatin

Refernces

• 1、 -. "Methods for predicting the response to statins". . . Retrieved 2011/10/13.
• 2、 -. "PROCESS FOR THE PREPARATION OF 1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8-[(2S)-2-METHYL-1-OXOBUTOXY]-, (BETA R,DELTA R,1S,2S,6S,8S,8AR)-1-NAPHTHALENEHEPTANOIC ACID, SODIUM SALT.". Page/Page column 8. . Retrieved 2008/06/13.