(S,E)-2-Methyl-6-(4-methylphenyl)-2-heptenal

Base Information

• Chemical Name: (S,E)-2-Methyl-6-(4-methylphenyl)-2-heptenal
• CAS No.: 25532-74-5
• Molecular Formula: C15H20 O
• Molecular Weight: 216.32
• Mol file: 25532-74-5.mol

Synonyms:2-Heptenal,2-methyl-6-(4-methylphenyl)-, [S-(E)]-; 2-Heptenal, 2-methyl-6-p-tolyl-,(E)-(+)- (8CI); Nuciferal (7CI); (+)-Nuciferal; (E)-Nuciferal;(E,S)-(+)-Nuciferal

Chemical Property of (S,E)-2-Methyl-6-(4-methylphenyl)-2-heptenal

Chemical Property:

• Boiling Point: 107.5 - 108.5 °C (0.03 mmHg)
• PSA: 17.07000
• LogP: 4.02390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S,E)-2-Methyl-6-(4-methylphenyl)-2-heptenal

There total 14 articles about (S,E)-2-Methyl-6-(4-methylphenyl)-2-heptenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S,E)-nuciferol (1786-15-8) → (+)-(S)-nuciferal (25532-74-5)

Guidance literature:

With manganese(IV) oxide; In tetrachloromethane; Heating;

Reference yield: 55.0%

propylidene-t-butylamine (7020-81-7) + (S)-4-p-tolylpentanal (3241-74-5,4895-19-6,122091-57-0,85799-06-0) → (+)-(S)-nuciferal (25532-74-5)

Guidance literature:

With lithium diisopropyl amide;

DOI:10.1016/S0040-4039(00)85896-7

Reference yield:

1-((S)-4-Benzyloxy-3-phenylsulfanyl-1-phenylsulfanylmethyl-butyl)-4-methyl-benzene (85764-98-3,91920-62-6) → (+)-(S)-nuciferal (25532-74-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Raney nickel(W-2) / ethanol / Heating

2: H₂,10percent palladized carbon

3: 1.) H₂, 2.) (COCl)2, Et₃N / 2.) DMSO

4: 55 percent / lithium diisopropylamide, acid

With palladium on activated charcoal; oxalyl dichloride; hydrogen; triethylamine; lithium diisopropyl amide; Raney nickel(W-2); In ethanol;

DOI:10.1016/S0040-4039(00)85896-7

upstream raw materials:

(S,Z)-2-methyl-6-(p-tolyl)hept-2-en-1-ol

propylidene-t-butylamine

(S)-4-p-tolylpentanal

((2-methylallyl)sulfinyl)benzene

Downstream raw materials:

(S,E)-nuciferol