4',6'-Dihydroxy-3'-(3-methyl-2-butenyl)-2'-methoxyacetophenone

Base Information

Chemical Name:4',6'-Dihydroxy-3'-(3-methyl-2-butenyl)-2'-methoxyacetophenone
CAS No.:27364-64-3
Molecular Formula:C₁₄H₁₈O₄
Molecular Weight:250.295
Hs Code.:2914509090
Mol file:27364-64-3.mol

Synonyms:Acetophenone,4',6'-dihydroxy-2'-methoxy-3'-(3-methyl-2-butenyl)- (7CI,8CI); Ethanone, 1-[4,6-dihydroxy-2-methoxy-3-(3-methyl-2-butenyl)phenyl]-(9CI); Acronylin

Suppliers and Price of 4',6'-Dihydroxy-3'-(3-methyl-2-butenyl)-2'-methoxyacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4',6'-Dihydroxy-3'-(3-methyl-2-butenyl)-2'-methoxyacetophenone

Chemical Property:

Melting Point:128–129°C
PSA：66.76000
LogP:2.81770

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4',6'-Dihydroxy-3'-(3-methyl-2-butenyl)-2'-methoxyacetophenone

There total 7 articles about 4',6'-Dihydroxy-3'-(3-methyl-2-butenyl)-2'-methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82538-76-9
2,4-dihydroxy-5-prenyl-3-iodo-6-methoxy-acetophenone

: 27364-64-3
1-[4,6-dihydroxy-2-methoxy-3-(3-methylbut-2-enyl)-phenyl]ethanone

Guidance literature:: With hydrogenchloride; zinc; In ethanol; for 0.5h; Heating;
DOI:10.1016/0040-4020(82)80200-7

Reference yield:

: 74047-32-8
2,4-dihydroxy-3-iodo-6-methoxyphenyl methyl ketone

: 27364-64-3
1-[4,6-dihydroxy-2-methoxy-3-(3-methylbut-2-enyl)-phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 0.15 g / BF_3.Et₂O / dioxane / 1 h / 35 - 40 °C

2: 0.2 g / Zn/cc. HCl / ethanol / 0.5 h / Heating

With hydrogenchloride; boron trifluoride diethyl etherate; zinc; In 1,4-dioxane; ethanol;
DOI:10.1016/0040-4020(82)80200-7

Reference yield:

: 27364-71-2
2',4',6'-trihydroxy-3'-(3-methyl-2-butenyl)acetophenone

: 27364-64-3
1-[4,6-dihydroxy-2-methoxy-3-(3-methylbut-2-enyl)-phenyl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

1.2: 0.75 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / Reflux; Inert atmosphere

3.1: hydrogenchloride; water / methanol / 1.5 h / Reflux; Inert atmosphere

With hydrogenchloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jnatprod.6b00646