8-AMino-Inosine

Base Information

• Chemical Name: 8-AMino-Inosine
• CAS No.: 13389-16-7
• Molecular Formula: C10H13N5O5
• Molecular Weight: 283.2407
• Mol file: 13389-16-7.mol

Synonyms:8-amino-9-pentofuranosyl-3,9-dihydro-6h-purin-6-one;8-amino-inosine;8-Amino-inosin;

Chemical Property of 8-AMino-Inosine

Chemical Property:

• Vapor Pressure: 1.42E-24mmHg at 25°C
• Melting Point: >215°C (dec.)
• Boiling Point: 764.5°Cat760mmHg
• Flash Point: 416.2°C
• PSA: 159.51000
• Density: 2.25g/cm³
• LogP: -2.10550
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

8-Amino-Inosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Amino-Inosine is an derivative of Inosine (I661000), a nucleoside that is found in tRNAs and is essential for the proper translation of genetic code in a wobble base pair. Inosine is also known to exert neuroprotective properties and has been used to treat stroke patients to restore neural function. 8-Amino-Inosine have been studied as a potential chemotherapeutic agent for the treatment of leukemia function by the cytodestruction of the neoplastic cells.

Technology Process of 8-AMino-Inosine

There total 3 articles about 8-AMino-Inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

8-benzylaminoinosine → 8-aminoinosine (13389-16-7)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In methanol; for 120h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.202000874

Reference yield: 36.0%

8-azidoinosine (97551-56-9) → 8-aminoinosine (13389-16-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water;

DOI:10.1021/jm00148a018

Reference yield:

→ 8-aminoinosine (13389-16-7)

Guidance literature:

8-Brom-inosin,H2N-NH2 in W. b. Siedetemp.;

DOI:10.1021/jo01284a024

upstream raw materials:

8-azidoinosine