1H-Inden-5-ol,1-[(1R)-1,5-dimethylhexyl]octahydro-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-,(1R,3aS,4S,5R,7aR)-

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Chemical Name:1H-Inden-5-ol,1-[(1R)-1,5-dimethylhexyl]octahydro-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-,(1R,3aS,4S,5R,7aR)-
CAS No.:126210-14-8
Molecular Formula:C27H44 O2
Molecular Weight:400.645
Hs Code.:

Synonyms:9,10-Secocholesta-1,3,5(10)-triene-3,9-diol,(9a)- (9CI); (-)-Astrogorgiadiol;Astrogorgiadiol

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Chemical Property of 1H-Inden-5-ol,1-[(1R)-1,5-dimethylhexyl]octahydro-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-,(1R,3aS,4S,5R,7aR)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Inden-5-ol,1-[(1R)-1,5-dimethylhexyl]octahydro-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-,(1R,3aS,4S,5R,7aR)-

There total 33 articles about 1H-Inden-5-ol,1-[(1R)-1,5-dimethylhexyl]octahydro-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-,(1R,3aS,4S,5R,7aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 328570-91-8
(1R,3aS,4S,5R,7aR)-4-(5-methoxy-2-methylphenethyl)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydro-1H-inden-5-ol

: 126210-14-8
Astrogorgadiol

Guidance literature:: With triethylsilane; tris(pentafluorophenyl)borate; In dichloromethane; for 1h;
DOI:10.1021/jo001519g

Reference yield:

: 2385-77-5
(R)-Citronellal

: 126210-14-8
Astrogorgadiol

Guidance literature:: Multi-step reaction with 12 steps

1.1: 92 percent / LiAlH₄ / tetrahydrofuran / 0 °C

2.1: Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 °C

3.1: NaH / tetrahydrofuran / 0.17 h

3.2: n-BuLi / tetrahydrofuran; hexane / 0.17 h

3.3: 31.3 g / tetrahydrofuran; hexane / 1 h / 20 °C

4.1: 26.4 g / Et₃N; MsN₃ / acetonitrile

5.1: Rh₂(S)-(PTPA)4 / CH₂Cl₂ / 12 h

5.2: 40 percent / aq. HCl; (S)-RuBINAP; H₂ / tetrahydrofuran; methanol / 517.15 Torr

6.1: 85 percent / K₂CO₃ / acetone / 5 h / Heating

7.1: NaCN / hexamethylphosphoric acid triamide / 5 h / 75 - 80 °C

7.2: 75 percent / KOH / methanol / 0.08 h / 20 °C

8.1: NaOMe / methanol / 0.17 h / 0 °C

8.2: methanol / 26 °C / Heating

9.1: 52 percent / CuCN; n-BuLi; DIBAL / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1 h / -20 °C

10.1: 84 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

11.1: 17.8 mg / L-Selectride / tetrahydrofuran / 3 h / -78 °C

12.1: 85 percent / Et₃SiH; tris(pentafluorophenyl)boron / CH₂Cl₂ / 1 h

With triethylsilane; dmap; lithium aluminium tetrahydride; n-butyllithium; dirhodium(II) tetrakis; tris(pentafluorophenyl)borate; sodium cyanide; hydrogen; sodium methylate; L-Selectride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; Methanesulfonyl azide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo001519g

Reference yield:

: 1117-61-9
(3R)-citronellol

: 126210-14-8
Astrogorgadiol

Guidance literature:: Multi-step reaction with 11 steps

1.1: Et₃N; DMAP / CH₂Cl₂ / 2 h / 0 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: n-BuLi / tetrahydrofuran; hexane / 0.17 h

2.3: 31.3 g / tetrahydrofuran; hexane / 1 h / 20 °C

3.1: 26.4 g / Et₃N; MsN₃ / acetonitrile

4.1: Rh₂(S)-(PTPA)4 / CH₂Cl₂ / 12 h

4.2: 40 percent / aq. HCl; (S)-RuBINAP; H₂ / tetrahydrofuran; methanol / 517.15 Torr

5.1: 85 percent / K₂CO₃ / acetone / 5 h / Heating

6.1: NaCN / hexamethylphosphoric acid triamide / 5 h / 75 - 80 °C

6.2: 75 percent / KOH / methanol / 0.08 h / 20 °C

7.1: NaOMe / methanol / 0.17 h / 0 °C

7.2: methanol / 26 °C / Heating

8.1: 52 percent / CuCN; n-BuLi; DIBAL / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1 h / -20 °C

9.1: 84 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

10.1: 17.8 mg / L-Selectride / tetrahydrofuran / 3 h / -78 °C

11.1: 85 percent / Et₃SiH; tris(pentafluorophenyl)boron / CH₂Cl₂ / 1 h

With triethylsilane; dmap; n-butyllithium; dirhodium(II) tetrakis; tris(pentafluorophenyl)borate; sodium cyanide; hydrogen; sodium methylate; L-Selectride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; Methanesulfonyl azide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo001519g