Chemical Property of Asukamycin
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:910°C at 760 mmHg
- PKA:3.80±0.30(Predicted)
- Flash Point:504.1°C
- PSA：145.33000
- Density:1.32g/cm3
- LogP:4.01570
- XLogP3:3.5
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:10
- Exact Mass:546.23660143
- Heavy Atom Count:40
- Complexity:1270
- Purity/Quality:
-
97% *data from raw suppliers
Asukamycin ≥95% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CCC(CC1)C=CC=CC=CC(=O)NC2=CC(C3C(C2=O)O3)(C=CC=CC=CC(=O)NC4=C(CCC4=O)O)O
- Isomeric SMILES:C1CCC(CC1)/C=C/C=C/C=C/C(=O)NC2=C[C@]([C@H]3[C@@H](C2=O)O3)(/C=C/C=C/C=C/C(=O)NC4=C(CCC4=O)O)O
-
Uses
Asukamycin is an unusual trienoic acid amide metabolite produced by Streptomyces nodosus, reported by Omura and colleagues at the Kitasato Institute, Japan, in 1976. Asukamycin belongs to the manumycin class that comprises two trienoic acid amides pivoted on a central cyclohexenone ring to give the molecule an unprecedented angular geometry. Asukamycin is active against Gram positive bacteria, tumor cell lines and protozoans, notably coccidia. Asukamycin’s cell toxicity is accompanied by activation of Caspases 3 and 8.
