SKF 83565C

Base Information

• Chemical Name: SKF 83565C
• CAS No.: 77969-41-6
• Molecular Formula: BrH*C₁₆H₁₅Cl₂NO₂
• Molecular Weight: 405.119
• Mol file: 77969-41-6.mol

Synonyms:

Chemical Property of SKF 83565C

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SKF 83565C

There total 4 articles about SKF 83565C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethylamino]-1-(3-chloro-phenyl)-ethanol (80751-53-7) → 6-Chloro-1-(3-chloro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide (77969-41-6)

Guidance literature:

With hydrogen bromide; at 135 ℃; for 3h;

DOI:10.1021/jm00346a005

Reference yield:

3-chlorostyrene oxide (20697-04-5) → 6-Chloro-1-(3-chloro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide (77969-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 h / 110 °C

2: 48percent aq. HBr / 3 h / 135 °C

With hydrogen bromide;

DOI:10.1021/jm00346a005

Reference yield:

2-(2-chloro-3,4-dimethoxyphenyl)ethylamine (67287-36-9) → 6-Chloro-1-(3-chloro-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide (77969-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 h / 110 °C

2: 48percent aq. HBr / 3 h / 135 °C

With hydrogen bromide;

DOI:10.1021/jm00346a005

upstream raw materials:

2-[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethylamino]-1-(3-chloro-phenyl)-ethanol

3-chlorostyrene oxide

2-(2-chloro-3,4-dimethoxyphenyl)ethylamine

m-Chlorobenzaldehyde

Refernces