METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

Base Information

• Chemical Name: METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE
• CAS No.: 121582-55-6
• Molecular Formula: C13H9F3N2O4
• Molecular Weight: 314.22
• Hs Code.: 2933990090
• Mol file: 121582-55-6.mol

Synonyms:AURORA KA-4785;METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE;METHYL 1,6-DIHYDRO-4-HYDROXY-1-[3-(TRIFLUOROMETHYL)PHENYL]-6-PYRIDAZIN ONE-3-CARBOXYLATE;Methyl 1,6-dihydro-4-hydroxy-6-oxo-1-[3-(trifluoromethyl)phenyl]pyridazin-3-carboxylate

Chemical Property of METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 119-121°C
• Boiling Point: 398.3°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 194.7°C
• PSA: 81.42000
• Density: 1.48g/cm³
• LogP: 1.74350
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

Methyl 1,6-dihydro-4-hydroxy-6-oxo-1-[3-(trifluoromethyl)phenyl]pyridazin-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

There total 5 articles about METHYL 4-HYDROXY-6-OXO-1-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

dimethyl 1-<3-(trifluoromethyl)phenyl>hydrazono-2-oxopropane-1,3-dicarboxylate (121582-47-6) → methyl 2-<3-(trifluoromethyl)phenyl>-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylate (121582-55-6)

Guidance literature:

In 1,2-dichloro-benzene; for 0.75h; Heating;

Reference yield: 71.0%

→ methyl 2-<3-(trifluoromethyl)phenyl>-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylate (121582-55-6)

Guidance literature:

In 1,2-dichloro-benzene; at 180 ℃; for 2h;

Reference yield:

C14H13F3N2O5 (121582-47-6) → methyl 2-<3-(trifluoromethyl)phenyl>-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylate (121582-55-6)

Guidance literature:

With methanol; sodium methylate; at 10 - 35 ℃; for 0.5h;

upstream raw materials:

dimethyl 1-<3-(trifluoromethyl)phenyl>hydrazono-2-oxopropane-1,3-dicarboxylate

3-oxopentanedioic acid dimethyl ester

3-trifluoromethylaniline

C₁₄H₁₃F₃N₂O₅

Downstream raw materials:

methyl 4-methoxy-6-oxo-1-[3-(trifluoromethyl)phenyl]-1,6-dihydropyridazine-3-carboxylate

6-Methoxycarbonyl-5-triphenylphosphoranylideneimino-2-(3-trifluoromethyl)phenylpyridazin-3(2H)-one

4-Azido-6-oxo-1-(3-trifluoromethyl-phenyl)-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester

4-Amino-6-oxo-1-(3-trifluoromethyl-phenyl)-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester

Refernces

• 1、 -. "Pyridazinone compounds". Page/Page column 66. . Retrieved 2010/08/08.