2-Oxo-1-phenylpyrrolidine-3-carboxylic acid

Base Information

Chemical Name:2-Oxo-1-phenylpyrrolidine-3-carboxylic acid
CAS No.:56137-52-1
Molecular Formula:C11H11 N O3
Molecular Weight:205.213
Hs Code.:
European Community (EC) Number:624-100-4
DSSTox Substance ID:DTXSID60971505
Mol file:56137-52-1.mol

Synonyms:56137-52-1;2-oxo-1-phenylpyrrolidine-3-carboxylic acid;1-Phenyl-2-oxo-3-pyrrolidinecarboxylic acid;2-Oxo-1-phenyl-3-pyrrolidinecarboxylic acid;3-Pyrrolidinecarboxylic acid, 2-oxo-1-phenyl-;BRN 0189006;5-22-06-00034 (Beilstein Handbook Reference);1-PHENYL-2-OXO-3-PYRROLIDINECARBOXYLIC;SCHEMBL308869;DTXSID60971505;KIXWRXJXMVUWCP-UHFFFAOYSA-N;MFCD01688147;AKOS000169771;AKOS017344800;2-oxo-1-phenylpyrrolidine-3-carboxylicacid;LS-137477;CS-0261791;FT-0657877;EN300-800037;A830933;1-Phenyl-2-oxo-3-pyrrolidinecarboxylic acid, 95%;2-oxidanylidene-1-phenyl-pyrrolidine-3-carboxylic acid

Suppliers and Price of 2-Oxo-1-phenylpyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Oxo-1-phenylpyrrolidine-3-carboxylicAcid
500mg
$ 155.00

Sigma-Aldrich
1-Phenyl-2-oxo-3-pyrrolidinecarboxylic acid 95%
1g
$ 77.70

Crysdot
2-Oxo-1-phenylpyrrolidine-3-carboxylicacid 97%
10g
$ 360.00

American Custom Chemicals Corporation
2-OXO-1-PHENYL PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
250MG
$ 129.56

American Custom Chemicals Corporation
2-OXO-1-PHENYL PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
25G
$ 3031.88

American Custom Chemicals Corporation
2-OXO-1-PHENYL PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
10G
$ 1964.66

American Custom Chemicals Corporation
2-OXO-1-PHENYL PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
5G
$ 1370.41

AK Scientific
2-oxo-1-Phenylpyrrolidine-3-carboxylicacid
10g
$ 712.00

AK Scientific
2-oxo-1-Phenylpyrrolidine-3-carboxylicacid
5g
$ 401.00

Total 18 raw suppliers

Chemical Property of 2-Oxo-1-phenylpyrrolidine-3-carboxylic acid

Chemical Property:

Vapor Pressure:1.34E-10mmHg at 25°C
Melting Point:142-146 °C(lit.)
Boiling Point:494.6°Cat760mmHg
Flash Point:252.9°C
PSA：57.61000
Density:1.343g/cm³
LogP:1.18910
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:205.07389321
Heavy Atom Count:15
Complexity:271

Purity/Quality:

99%, ^*data from raw suppliers

2-Oxo-1-phenylpyrrolidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CN(C(=O)C1C(=O)O)C2=CC=CC=C2

Technology Process of 2-Oxo-1-phenylpyrrolidine-3-carboxylic acid

There total 5 articles about 2-Oxo-1-phenylpyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

: 5617-70-9
cycl-isopropylidene cyclopropane-1,1-dicarboxylate

: 62-53-3
aniline

: 56137-52-1
1-phenyl-2-oxo-3-pyrrolidine-3-carboxylic acid

Guidance literature:: In N,N-dimethyl-formamide; at 30 - 35 ℃; for 12h;
DOI:10.1016/j.bioorg.2020.103970

Reference yield:

: 146653-73-8
N,N'-bis(phenyl)cyclopropane-1,1-diamide

: 598-10-7
cyclopropane-1,1-dicarboxylic acid

: 56137-52-1
1-phenyl-2-oxo-3-pyrrolidine-3-carboxylic acid

Guidance literature:: With hydrogen bromide; at 130 ℃;

Reference yield:

: 4641-57-0
1-phenylpyrrolidin-2-one

: 56137-52-1
1-phenyl-2-oxo-3-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / toluene / 1 h / 0 °C / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / methanol; water / 20 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; In methanol; water; toluene;
DOI:10.1021/acs.orglett.5b03080