S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate

Base Information

Chemical Name:S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate
CAS No.:127227-39-8
Molecular Formula:C₂₃H₁₇ClN₆O₂S₂
Molecular Weight:509.012
Hs Code.:
Mol file:127227-39-8.mol

S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate

Synonyms:Ethanethioicacid, [(2-chlorophenyl)amino]-,S-[5-[4,5-dihydro-4-(1H-indol-3-ylmethylene)-2-methyl-5-oxo-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl]ester (9CI)

Suppliers and Price of S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate

Chemical Property:

Vapor Pressure:1.34E-23mmHg at 25°C
Boiling Point:769.5°Cat760mmHg
Flash Point:419.2°C
Density:1.56g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate

There total 3 articles about S-{5-[(4E)-4-(1H-indol-3-ylmethylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl} [(2-chlorophenyl)amino]ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 127227-45-6
(2-Chloro-phenylamino)-acetyl chloride

: 127227-36-5
3-<4'-(1''H-indol-3''-ylmethylene)-2'-methyl-5'-(4'H)-oxo-1'H-imidazol-1'-yl>-5-mercapto-1,3,4-thiadiazole

: 127227-39-8
(2-Chloro-phenylamino)-thioacetic acid S-(5-{4-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-yl) ester

Guidance literature:: With potassium carbonate; In acetone; for 4h; Heating;

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 127227-39-8
(2-Chloro-phenylamino)-thioacetic acid S-(5-{4-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / sodium acetate, acetic anhydride / 2 h / Heating

2: 70 percent / 0.33 h / 140 °C / Heating

3: 60 percent / K₂CO₃ / acetone / 4 h / Heating

With sodium acetate; acetic anhydride; potassium carbonate; In acetone;

Reference yield:

: 54753-57-0,70082-68-7,70082-69-8
4-(1'H-indol-3'-ylmethylene)-2-methyl-5(4H)oxazolone

: 127227-39-8
(2-Chloro-phenylamino)-thioacetic acid S-(5-{4-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 0.33 h / 140 °C / Heating

2: 60 percent / K₂CO₃ / acetone / 4 h / Heating

With potassium carbonate; In acetone;