5-(Carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid

Base Information

• Chemical Name: 5-(Carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
• CAS No.: 1634-89-5
• Molecular Formula: C15H18 N2 O7
• Molecular Weight: 338.317
• Hs Code.: 2924299090
• NSC Number: 186902
• DSSTox Substance ID: DTXSID40307080
• Mol file: 1634-89-5.mol

Synonyms:NSC186902;1634-89-5;5-(carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid;SCHEMBL14433709;DTXSID40307080;NSC-186902

Chemical Property of 5-(Carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid

Chemical Property:

• Vapor Pressure: 1.81E-21mmHg at 25°C
• Boiling Point: 715.2°Cat760mmHg
• PKA: 3.35±0.10(Predicted)
• Flash Point: 386.3°C
• PSA: 142.03000
• Density: 1.377g/cm³
• LogP: 1.12880
• Storage Temp.: -15°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 338.11140092
• Heavy Atom Count: 24
• Complexity: 461

Purity/Quality:

99%+, ^*data from raw suppliers

Z-Glu-Gly-OH 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(CCC(=O)O)C(=O)NCC(=O)O

Technology Process of 5-(Carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid

There total 19 articles about 5-(Carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

Z-L-GluOMe (5672-83-3) + glycine hydrobromide (17219-65-7) → Z-(S)-Glu-Gly (1634-89-5)

Guidance literature:

With Staphylococcus aureus V₈ proteinase; triethylamine; In water; acetonitrile; at 30 ℃; for 24h;

DOI:10.1016/S0040-4039(00)92725-4

Reference yield:

N-[N-(N-benzyloxycarbonyl-α-L-glutamyl)-glycyl]-glycine (908571-04-0) + acetic acid-[(25R)-5α-spirosta-7,9(11)-dien-3β-yl ester (89714-94-3) → N-benzyloxycarbonyl-L-glutamic acid (1155-62-0) + Z-(S)-Glu-Gly (1634-89-5)

Guidance literature:

Hydrolysis;

Reference yield:

N-(N-benzyloxycarbonyl-α-L-glutamyl)-glycine ethyl ester (4587-40-0) → Z-(S)-Glu-Gly (1634-89-5)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

Z-L-Glu(OEt)-Gly-OEt

N-(N-benzyloxycarbonyl-α-L-glutamyl)-glycine ethyl ester

N-[N-(N-benzyloxycarbonyl-α-L-glutamyl)-glycyl]-glycine

acetic acid-[(25R)-5α-spirosta-7,9(11)-dien-3β-yl ester

Downstream raw materials:

N-benzyloxycarbonyl-L-glutamic acid

Glu-Gly

Refernces

• 1、 -. "MODIFICATION OF ENZYMATIC CROSSLINKERS FOR CONTROLLING PROPERTIES OF CROSSLINKED MATRICES". . . Retrieved 2012/11/07.
• 2、 Cerovsky, Vaclav. "V8 PROTEINASE-CATALYZED PEPTIDE SYNTHESIS IN HYDROPHILIC ORGANIC SOLVENTS WITH LOW WATER CONTENT". . p. 3421 - 3424. Retrieved 2007/10/02.