2-(3,4-Dihydroxyphenyl)acetamide

Base Information

• Chemical Name: 2-(3,4-Dihydroxyphenyl)acetamide
• CAS No.: 1129-53-9
• Molecular Formula: C8H9 N O3
• Molecular Weight: 167.164
• Hs Code.: 2924299090
• European Community (EC) Number: 214-451-8
• DSSTox Substance ID: DTXSID90150205
• Nikkaji Number: J203.373I
• Wikidata: Q15726091
• Mol file: 1129-53-9.mol

Synonyms:2-(3,4-Dihydroxyphenyl)acetamide;1129-53-9;3,4-DIHYDROXYPHENYLACETAMIDE;EINECS 214-451-8;Dopacetamide;3,4-Dihydroxybenzeneacetamide;SCHEMBL2734611;DTXSID90150205;CHEBI:183417;AKOS006281044;FT-0699525;EN300-732951;F73765

Chemical Property of 2-(3,4-Dihydroxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 9.25E-10mmHg at 25°C
• Boiling Point: 478°Cat760mmHg
• Flash Point: 242.9°C
• PSA: 83.55000
• Density: 1.394g/cm³
• LogP: 0.82590
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CC(=O)N)O)O

Technology Process of 2-(3,4-Dihydroxyphenyl)acetamide

There total 9 articles about 2-(3,4-Dihydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-Dibenzyloxy-phenylacetamid (14745-25-6) → 3,4-dihydroxyphenylacetamide (1129-53-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1002/hlca.19620450133

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → 3,4-dihydroxyphenylacetamide (1129-53-9)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / methanol

2: (i) SOCl₂, Et₂O, (ii) /BRN= 3587243/, NaI, MeCOEt

3: aq. KOH / methanol; dioxane

4: (i) SOCl₂, benzene, (ii) aq. NH₃

5: H₂ / Pd-C / ethanol

With potassium hydroxide; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;

DOI:10.1002/hlca.19620450133

Reference yield:

3,4-bis(benzyloxy)benzyl alcohol (1699-58-7) → 3,4-dihydroxyphenylacetamide (1129-53-9)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) SOCl₂, Et₂O, (ii) /BRN= 3587243/, NaI, MeCOEt

2: aq. KOH / methanol; dioxane

3: (i) SOCl₂, benzene, (ii) aq. NH₃

4: H₂ / Pd-C / ethanol

With potassium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;

DOI:10.1002/hlca.19620450133

upstream raw materials:

3,4-Dibenzyloxy-phenylacetamid

2-(3,4-dihydroxyphenyl)acetic acid methyl ester

3,4-dibenzyloxybenzaldehyde

3,4-bis(benzyloxy)benzyl alcohol

Downstream raw materials:

N-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-dimethylpropyl)-2-(3,4-dihydroxyphenyl)acetamide