Deprodone

Base Information

Chemical Name:Deprodone
CAS No.:20423-99-8
Molecular Formula:C21H28O4
Molecular Weight:344.451
Hs Code.:
European Community (EC) Number:243-809-6
UNII:Z380L7N00P
DSSTox Substance ID:DTXSID101043210
Nikkaji Number:J10.943F
Wikipedia:Deprodone
Wikidata:Q27294935
NCI Thesaurus Code:C77412
Metabolomics Workbench ID:155793
ChEMBL ID:CHEMBL2105540
Mol file:20423-99-8.mol

Synonyms:Deprodone;20423-99-8;21-Deoxyprednisolone;Deprodonum;Deprodona;DESOLONE;21-Desoxyprednisolone;Deprodone [INN:BAN];Deprodonum [INN-Latin];Deprodona [INN-Spanish];UNII-Z380L7N00P;Z380L7N00P;EINECS 243-809-6;(8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;11beta,17-Dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-, (11.beta.)-;Deprodone [BAN:INN];DEPRODONE [INN];DEPRODONE [MART.];DEPRODONE [WHO-DD];SCHEMBL121194;CHEMBL2105540;DTXSID101043210;AKOS025402047;AC-3526;PREDNISOLONE ACETATE IMPURITY D [EP IMPURITY];Q27294935;11.BETA.,17-DIHYDROXYPREGNA-1,4-DIENE3,20-DIONE;Pregna-1,4-diene-3,20-dione, 11.beta.,17-dihydroxy-;11.BETA.,17-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;(8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Suppliers and Price of Deprodone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
21-Deoxyprednisolone
10mg
$ 185.00

TRC
21-Deoxyprednisolone
100mg
$ 1455.00

American Custom Chemicals Corporation
DEPRODONE 95.00%
5MG
$ 497.75

Total 45 raw suppliers

Chemical Property of Deprodone

Chemical Property:

Vapor Pressure:2.54E-13mmHg at 25°C
Refractive Index:1.592
Boiling Point:527.3 °C at 760 mmHg
Flash Point:286.8 °C
PSA：80.67000
Density:1.24 g/cm³
LogP:3.54610
Storage Temp.:-20°C Freezer
Solubility.:Acetonitrile (Slightly), Dioxane (Slightly), DMSO (Slightly)
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:344.19875937
Heavy Atom Count:25
Complexity:707

Purity/Quality:

98%,99%, ^*data from raw suppliers

21-Deoxyprednisolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)O
Isomeric SMILES:CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)O
Uses Deprodone is an analog of Prednisolone (P703740), a synthetic corticosteroid; metabolically interconvertible with Prednisone (P703780). It is also used in the synthesis of another corticost eroid, anti-inflammatory, Rimexolone (R422500). 21-Deoxyprednisolone is an analog of Prednisolone (P703740), a synthetic corticosteroid; metabolically interconvertible with Prednisone (P703780). It is also used in the synthesis of another corticosteroid, anti-inflammatory, Rimexolone (R422500).

Technology Process of Deprodone

There total 14 articles about Deprodone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₆Br₂O₄

: 20423-99-8
11β,17α-dihydroxypregna-1,4-diene-3,20-dione

Guidance literature:: With pyridine; 5%-palladium/activated carbon; hydrogen; In ethanol; at 50 - 55 ℃; under 2280.15 - 2660.18 Torr; Reagent/catalyst;

Reference yield:

: 49757-06-4
11β,17α-dihydoxy-21-iodopregna-1,4-diene-3,10-dione

: 20423-99-8
11β,17α-dihydroxypregna-1,4-diene-3,20-dione

Guidance literature:: With acetic acid; sodium iodide; In acetone; Heating;
DOI:10.1021/jo981848x

Reference yield:

: 50-24-8,8056-11-9
prednisolon

: 20423-99-8
11β,17α-dihydroxypregna-1,4-diene-3,20-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 5 °C

2: NaI / acetone / 20 °C

3: NaI; HOAc / acetone / Heating

With pyridine; acetic acid; sodium iodide; In acetone; 1: Tosylation / 2: Substitution / 3: Dehalogenation;
DOI:10.1021/jo981848x