4,6-Dichloropyrimidin-2(1h)-one

Base Information

Chemical Name:4,6-Dichloropyrimidin-2(1h)-one
CAS No.:6297-80-9
Molecular Formula:C4H2Cl2N2O
Molecular Weight:164.9775
Hs Code.:2933599090
NSC Number:45721
DSSTox Substance ID:DTXSID00286423
Wikidata:Q82022141
Mol file:6297-80-9.mol

Synonyms:4,6-dichloropyrimidin-2(1h)-one;6297-80-9;4,6-Dichloropyrimidin-2-ol;4,6-dichloro-1H-pyrimidin-2-one;NSC45721;2(1H)-Pyrimidinone, 4,6-dichloro-;MFCD14702755;4,6-dichloro-1,2-dihydropyrimidin-2-one;AMY221;SCHEMBL7891944;DTXSID00286423;NSC-45721;AKOS006330027;CS-W006788;MB14179;AS-56009;SY113399;FT-0718088;EN300-310100;A868288

Suppliers and Price of 4,6-Dichloropyrimidin-2(1h)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,6-Dichloro-2-hydroxypyrimidine
500mg
$ 170.00

Matrix Scientific
4,6-Dichloropyrimidin-2(1H)-one 95+%
1g
$ 1350.00

Crysdot
4,6-Dichloropyrimidin-2(1H)-one 97%
1g
$ 325.00

Chemenu
4,6-dichloropyrimidin-2(1H)-one 97%
1g
$ 307.00

American Custom Chemicals Corporation
4,6-DICHLOROPYRIMIDIN-2(1H)-ONE 95.00%
5MG
$ 504.49

Ambeed
4,6-Dichloropyrimidin-2(1H)-one 95%
250mg
$ 130.00

Ambeed
4,6-Dichloropyrimidin-2(1H)-one 95%
100mg
$ 86.00

Ambeed
4,6-Dichloropyrimidin-2(1H)-one 95%
1g
$ 343.00

AK Scientific
4,6-Dichloropyrimidin-2-ol
1g
$ 523.00

AK Scientific
4,6-Dichloropyrimidin-2-ol
250mg
$ 235.00

Total 20 raw suppliers

Chemical Property of 4,6-Dichloropyrimidin-2(1h)-one

Chemical Property:

Melting Point:157 °C
Boiling Point:°Cat760mmHg
PKA:4.97±0.10(Predicted)
Flash Point:°C
PSA：45.75000
Density:1.76g/cm³
LogP:1.07670
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:163.9544181
Heavy Atom Count:9
Complexity:209

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dichloro-2-hydroxypyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(NC(=O)N=C1Cl)Cl
Uses 4,6-Dichloro-2-hydroxypyrimidine is a useful building block used in the preparation of diaminopyrimidinone IRAK4 inhibitors. An isomer of 5-Chlorouracil (C423775).

Technology Process of 4,6-Dichloropyrimidin-2(1h)-one

There total 4 articles about 4,6-Dichloropyrimidin-2(1h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3764-01-0
2,4,6-trichloropyrimidine

: 6297-80-9
4,6-dichloropyrimidin-2(1H)-one

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; for 48h;

Reference yield:

: 3764-01-0
2,4,6-trichloropyrimidine

: 6297-80-9
4,6-Dichlor-pyrimidinol-(2)

Guidance literature:: With sodium hydrogencarbonate; sodium carbonate; In water; acetone; at 40 ℃; Rate constant; other substituting agents, var. solvents, var. time;

Reference yield:

: 3764-01-0
2,4,6-trichloropyrimidine

: 6297-80-9
4,6-dichloropyrimidin-2(1H)-one

: 2,6-dichloropyrimidin-4(3H)-one

Guidance literature:: With hydrogenchloride; sodium hydroxide; water; Yield given. Multistep reaction. Yields of byproduct given; 1.) dioxane, 2.) H₂O, pH=2;
DOI:10.1002/hlca.19890720414