4,4'-Dihydroxy-3,5,3',5'-tetramethoxydiphenylmethane

Base Information

• Chemical Name: 4,4'-Dihydroxy-3,5,3',5'-tetramethoxydiphenylmethane
• CAS No.: 15640-40-1
• Molecular Formula: C17H20 O6
• Molecular Weight: 320.342
• Hs Code.: 2909500000
• NSC Number: 156573
• DSSTox Substance ID: DTXSID70935436
• Nikkaji Number: J111.553G
• Wikidata: Q82911481
• ChEMBL ID: CHEMBL1978946
• Mol file: 15640-40-1.mol

Synonyms:4,4'-Dihydroxy-3,5,3',5'-tetramethoxydiphenylmethane;15640-40-1;4,4'-Methylenebis(2,6-dimethoxyphenol);MLS003106435;4-[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-2,6-dimethoxyphenol;NSC156573;SCHEMBL7702890;CHEMBL1978946;DTXSID70935436;NDYPCLQAPPEYLS-UHFFFAOYSA-N;NSC-156573;4,5,3',5'-tetramethoxydiphenylmethane;Phenol,4'-methylenebis[2,6-dimethoxy-;SMR001821338;Phenol, 4,4'-methylenebis*2,6-dimethoxy-;Phenol, 4,4'-methylenebis[2,6-dimethoxy-

Chemical Property of 4,4'-Dihydroxy-3,5,3',5'-tetramethoxydiphenylmethane

Chemical Property:

• Boiling Point: 491.8°Cat760mmHg
• Flash Point: 251.3°C
• PSA: 77.38000
• Density: 1.224g/cm³
• LogP: 2.72300
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 320.12598835
• Heavy Atom Count: 23
• Complexity: 292

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1O)OC)CC2=CC(=C(C(=C2)OC)O)OC

Technology Process of 4,4'-Dihydroxy-3,5,3',5'-tetramethoxydiphenylmethane

There total 21 articles about 4,4'-Dihydroxy-3,5,3',5'-tetramethoxydiphenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) + 2,6-dimethoxy-4-<(N,N-dimethylamino)methyl>phenol hydrochloride → bis(4-hydroxy-2,6-dimethoxyphenyl)methane (15640-40-1)

Guidance literature:

With sodium methylate; In ethylene glycol; at 140 ℃; for 8h;

Reference yield: 85.0%

2,6-dimethoxy-4-<(N,N-dimethylamino)methyl>phenol hydrochloride → bis(4-hydroxy-2,6-dimethoxyphenyl)methane (15640-40-1)

Guidance literature:

With sodium methylate; In ethylene glycol; at 140 ℃; for 1h;

DOI:10.1021/jm00178a007

Reference yield: 78.0%

2,6-dimethoxy-4-<(N,N-dimethylamino)methyl>phenol (39667-14-6) + 2,4-dihydroxy-6-methylpyrimidine (626-48-2) → bis(4-hydroxy-2,6-dimethoxyphenyl)methane (15640-40-1) + 5-(4-Hydroxy-3,5-dimethoxy-benzyl)-6-methyl-pyrimidine-2,4-diol

Guidance literature:

In ethylene glycol; at 140 - 160 ℃;

DOI:10.1021/jm00178a007

upstream raw materials:

1,3-dimethoxy-2-hydroxy-benzene

4-aminopyridine

2,6-dimethoxy-4-<(N,N-dimethylamino)methyl>phenol

2,4-diaminopyrimidine

Downstream raw materials:

bis-(4-acetoxy-3,5-dimethoxy-phenyl)-methane

bis(3,4,5-trimethoxyphenyl)methane