(2S)-5-Methylpyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S)-5-Methylpyrrolidine-2-carboxylic acid
CAS No.:16639-15-9
Molecular Formula:C₆H₁₁NO₂
Molecular Weight:129.159
Hs Code.:
DSSTox Substance ID:DTXSID10937191
Mol file:16639-15-9.mol

Synonyms:(2S)-5-Methylpyrrolidine-2-carboxylic acid;5-Methylproline;Proline, 5-methyl-;681128-94-9;16639-15-9;5-Methyl-prolin;(2S)-5-METHYLPYRROLIDINE-2-CARBOXYLICACID;SCHEMBL1467724;DTXSID10937191;YNSYWEFVEIFJPZ-AKGZTFGVSA-N;AKOS006275457;AC-15700

Suppliers and Price of (2S)-5-Methylpyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S)-5-Methylpyrrolidine-2-carboxylic acid

Chemical Property:

Vapor Pressure:0.00694mmHg at 25°C
Boiling Point:250.2°Cat760mmHg
Flash Point:105.1°C
Density:1.104g/cm³
XLogP3:-1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:129.078978594
Heavy Atom Count:9
Complexity:124

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCC(N1)C(=O)O
Isomeric SMILES:CC1CC[C@H](N1)C(=O)O

Technology Process of (2S)-5-Methylpyrrolidine-2-carboxylic acid

There total 7 articles about (2S)-5-Methylpyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 296775-02-5
methyl 5-oxo-2-[N-(9-(9-phenylfluorenyl))amino]hexanoate

: 7244-99-7,13532-58-6,13532-74-6,16639-15-9,28115-34-6,38228-16-9,38533-00-5,38533-38-9,49669-55-8
cis-5-methylproline

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Pd/C / methanol / 48 h / 3040 Torr

2: 96 percent / KOSiMe₃ / diethyl ether / 18 h / 20 °C

3: TFA / CH₂Cl₂

With potassium trimethylsilonate; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1139/v00-176

Reference yield:

: 5-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-hexanoic acid

: 7244-99-7,13532-58-6,13532-74-6,16639-15-9,28115-34-6,38228-16-9,38533-00-5,38533-38-9,49669-55-8
cis-5-methylproline

Guidance literature:: Multi-step reaction with 4 steps

1: 259 mg / K₂CO₃ / acetonitrile / 18 h / 20 °C

2: 92 percent / H₂ / Pd/C / methanol / 48 h / 3040 Torr

3: 96 percent / KOSiMe₃ / diethyl ether / 18 h / 20 °C

4: TFA / CH₂Cl₂

With potassium trimethylsilonate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1139/v00-176

Reference yield:

: 296774-83-9
methyl 5-oxo-4-(methyloxycarbonyl)-2-[N-(9-phenylfluoren-9-yl)amino]hexanoate

: 7244-99-7,13532-58-6,13532-74-6,16639-15-9,28115-34-6,38228-16-9,38533-00-5,38533-38-9,49669-55-8
cis-5-methylproline

Guidance literature:: Multi-step reaction with 5 steps

1: 1N NaOH / ethanol / 5 h / Heating

2: 259 mg / K₂CO₃ / acetonitrile / 18 h / 20 °C

3: 92 percent / H₂ / Pd/C / methanol / 48 h / 3040 Torr

4: 96 percent / KOSiMe₃ / diethyl ether / 18 h / 20 °C

5: TFA / CH₂Cl₂

With sodium hydroxide; potassium trimethylsilonate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane; acetonitrile;
DOI:10.1139/v00-176