[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy -[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2- yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan- 2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxola n-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxo lan-2-yl]methoxyphosphonic acid

Base Information

• Chemical Name: [(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy -[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2- yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan- 2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxola n-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxo lan-2-yl]methoxyphosphonic acid
• CAS No.: 2945-57-5
• Molecular Formula: C₄₀H₅₄N₈O₂₉P₄
• Molecular Weight: 1234.8
• Mol file: 2945-57-5.mol

Synonyms:5'-Thymidylicacid, tetramol. 3',5''':3''',5''''':3''''',5'''''''-ester (6CI); 5'-Thymidylicacid, thymidylyl-(5'®3')-thymidylyl-(5'®3')-thymidylyl-(5'®3')-; Thymidine, 5'-O-phosphorylthymidylyl-(3'®5')-thymidylyl-(3'®5')-thymidylyl-(3'®5')- (7CI,8CI); Tetrathymidylic acid, pTpTpTpT;d(PT)4; pTpTpTpT

Chemical Property of [(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy -[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2- yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan- 2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxola n-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxo lan-2-yl]methoxyphosphonic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 549.87000
• Density: 1.8g/cm³
• LogP: -2.45240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy -[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2- yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan- 2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxola n-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxo lan-2-yl]methoxyphosphonic acid

There total 4 articles about [(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy -[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2- yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan- 2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxola n-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxo lan-2-yl]methoxyphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C44H61N9O29P4 → 5'-O-Phosphoryl-thymidylyl-(3'-5')-thymidylyl-(3'-5')-thymidylyl-(3'-5')-thymidin (2945-57-5,153676-80-3)

Guidance literature:

With hydrogenchloride; for 1h; Yield given; pH 2;

DOI:10.1016/S0040-4039(01)90351-X

Reference yield:

C51H65N9O30P4 → 5'-O-Phosphoryl-thymidylyl-(3'-5')-thymidylyl-(3'-5')-thymidylyl-(3'-5')-thymidin (2945-57-5,153676-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃ / 48 h / 50 °C

2: 0.1 N HCl / 1 h / pH 2

With hydrogenchloride; ammonium hydroxide;

DOI:10.1016/S0040-4039(01)90351-X

Reference yield:

C65H68Cl3N8O33P5 → ppTTTT (78632-85-6) + 5'-O-Phosphoryl-thymidylyl-(3'-5')-thymidylyl-(3'-5')-thymidylyl-(3'-5')-thymidin (2945-57-5,153676-80-3)

Guidance literature:

With ammonium hydroxide; 4-nitrobenzaldoxime; Yield given. Multistep reaction; 1.) 48 h; 2.) 5O deg C, 48 h;

DOI:10.1016/S0040-4039(01)90351-X