Malyngamide L

Base Information

Chemical Name:Malyngamide L
CAS No.:200409-81-0
Molecular Formula:C₂₆H₄₂ClNO₄
Molecular Weight:468.077
Hs Code.:

Synonyms:

Suppliers and Price of Malyngamide L

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Malyngamide L

Chemical Property:

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Technology Process of Malyngamide L

There total 10 articles about Malyngamide L which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1303528-37-1
(4E,7S)-N-{(2Z)-[(3S,4S)-4-allyloxy-3-methyl-2-oxocyclohex-1-enyl]-2-chloromethyleneethyl}-N-methyl-7-methoxytetradec-4-enamide

: 200409-81-0
(4E,7S)-N-{(2Z)-[(3S,4S)-4-hydroxy-3-methyl-2-oxocyclohex-1-enyl]-2-chloromethyleneethyl}-N-methyl-7-methoxytetradec-4-enamide

Guidance literature:: With methanol; palladium dichloride; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1021/jo2003852

Reference yield:

: 1303528-30-4
(5S,6S)-5-methoxymethoxy-6-methylcyclohex-2-enone

: 200409-81-0
(4E,7S)-N-{(2Z)-[(3S,4S)-4-hydroxy-3-methyl-2-oxocyclohex-1-enyl]-2-chloromethyleneethyl}-N-methyl-7-methoxytetradec-4-enamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; triethylamine / dichloromethane / 0.08 h / 0 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / -78 - 20 °C

3.1: methanol; potassium carbonate / 2 h / 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 0 - 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 °C / Inert atmosphere

6.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / toluene / 30 h / 20 °C / Inert atmosphere

7.1: methanol; palladium dichloride / dichloromethane / 7 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; bromine; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; palladium dichloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 6.1: Suzuki cross-coupling;
DOI:10.1021/jo2003852

Reference yield:

: 2244-16-8,6485-40-1
(S)-p-mentha-6,8-dien-2-one

: 200409-81-0
(4E,7S)-N-{(2Z)-[(3S,4S)-4-hydroxy-3-methyl-2-oxocyclohex-1-enyl]-2-chloromethyleneethyl}-N-methyl-7-methoxytetradec-4-enamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: dihydrogen peroxide; sodium hydroxide / methanol / 0.83 h / -20 °C

1.2: 1.5 h / 20 °C / Inert atmosphere

2.1: ozone / methanol; dichloromethane / -78 °C

2.2: -20 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4.1: bromine; triethylamine / dichloromethane / 0.08 h / 0 °C

5.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / -78 - 20 °C

6.1: methanol; potassium carbonate / 2 h / 0 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

7.2: 0 - 20 °C

8.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

8.2: 2 h / -78 °C / Inert atmosphere

9.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / toluene / 30 h / 20 °C / Inert atmosphere

10.1: methanol; palladium dichloride / dichloromethane / 7 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; dihydrogen peroxide; bromine; palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium dichloride; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 9.1: Suzuki cross-coupling;
DOI:10.1021/jo2003852