N~1~-[5-({3-[(3-{[N~5~-(diaminomethylidene)ornithyl]amino}propyl)amino]propyl}amino)pentyl]-N~2~-[(4-hydroxy-1H-indol-3-yl)acetyl]aspartamide

Base Information

Chemical Name:N~1~-[5-({3-[(3-{[N~5~-(diaminomethylidene)ornithyl]amino}propyl)amino]propyl}amino)pentyl]-N~2~-[(4-hydroxy-1H-indol-3-yl)acetyl]aspartamide
CAS No.:117306-99-7
Molecular Formula:C₃₁H₅₃N₁₁O₅
Molecular Weight:659.833
Hs Code.:

N~1~-[5-({3-[(3-{[N~5~-(diaminomethylidene)ornithyl]amino}propyl)amino]propyl}amino)pentyl]-N~2~-[(4-hydroxy-1H-indol-3-yl)acetyl]aspartamide

Synonyms:ArgiopininIII

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Chemical Property of N~1~-[5-({3-[(3-{[N~5~-(diaminomethylidene)ornithyl]amino}propyl)amino]propyl}amino)pentyl]-N~2~-[(4-hydroxy-1H-indol-3-yl)acetyl]aspartamide

Chemical Property:

Density:1.37g/cm³

Purity/Quality:

Safty Information:

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Technology Process of N~1~-[5-({3-[(3-{[N~5~-(diaminomethylidene)ornithyl]amino}propyl)amino]propyl}amino)pentyl]-N~2~-[(4-hydroxy-1H-indol-3-yl)acetyl]aspartamide

There total 12 articles about N~1~-[5-({3-[(3-{[N~5~-(diaminomethylidene)ornithyl]amino}propyl)amino]propyl}amino)pentyl]-N~2~-[(4-hydroxy-1H-indol-3-yl)acetyl]aspartamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 111944-83-3,117306-99-7
Argiotoxin 659

Guidance literature:: Multi-step reaction with 12 steps

1: 99 percent / NaBH₄, MgSO₄ / methanol

2: 79 percent / KF, celite / acetonitrile / 82 °C

3: NH₂NH₂ / methanol / 50 °C

4: NaBH₄, MgSO₄ / methanol

5: KF, celite / acetonitrile / 82 °C

6: NH₂NH₂ / methanol / 50 °C

7: 88 percent / CH₂Cl₂

8: TFA

9: TEA / CH₂Cl₂

10: TFA

11: 71 percent / HOBt, DCC / CH₂Cl₂

12: Hydrogen / Pd(OH)2 / acetic acid

With potassium fluoride; sodium tetrahydroborate; Celite; TEA; hydrogen; magnesium sulfate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; hydrazine; palladium dihydroxide; In methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1016/S0040-4039(00)82310-2

Reference yield:

: C₇₆H₈₉N₁₁O₁₁

: 111944-83-3,117306-99-7
Argiotoxin 659

Guidance literature:: With hydrogen; palladium dihydroxide; In acetic acid;
DOI:10.1016/S0040-4039(00)82310-2

Reference yield:

: 122631-98-5
N¹-benzyl-N⁵-(tert-butoxycarbonyl)-1,5-diaminopentane

: 111944-83-3,117306-99-7
Argiotoxin 659

Guidance literature:: Multi-step reaction with 11 steps

1: 79 percent / KF, celite / acetonitrile / 82 °C

2: NH₂NH₂ / methanol / 50 °C

3: NaBH₄, MgSO₄ / methanol

4: KF, celite / acetonitrile / 82 °C

5: NH₂NH₂ / methanol / 50 °C

6: 88 percent / CH₂Cl₂

7: TFA

8: TEA / CH₂Cl₂

9: TFA

10: 71 percent / HOBt, DCC / CH₂Cl₂

11: Hydrogen / Pd(OH)2 / acetic acid

With potassium fluoride; sodium tetrahydroborate; Celite; TEA; hydrogen; magnesium sulfate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; hydrazine; palladium dihydroxide; In methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1016/S0040-4039(00)82310-2