2-(2-Hydroxyphenoxy)acetic acid

Base Information

• Chemical Name: 2-(2-Hydroxyphenoxy)acetic acid
• CAS No.: 6324-11-4
• Molecular Formula: C8H8O4
• Molecular Weight: 168.149
• Hs Code.: 2918990090
• European Community (EC) Number: 228-684-8
• NSC Number: 30092
• DSSTox Substance ID: DTXSID80212629
• Nikkaji Number: J265.555A
• Wikidata: Q83087776
• ChEMBL ID: CHEMBL1604900
• Mol file: 6324-11-4.mol

Synonyms:6324-11-4;2-Hydroxyphenoxyacetic Acid;2-(2-hydroxyphenoxy)acetic acid;(2-Hydroxyphenoxy)acetic acid;Acetic acid, (hydroxyphenoxy)-;(o-Hydroxyphenoxy)acetic acid;Enamine_004711;2-(carboxymethoxy)phenol;Cambridge id 5156176;2-hydroxyphenoxy acetic acid;Oprea1_081061;MLS000105508;(2-hydroxyphenoxy) acetic acid;2-(2-hydroxyphenoxy)aceticacid;SCHEMBL1123330;CHEMBL1604900;DTXSID80212629;Acetic acid, (2-hydroxyphenoxy)-;HMS1407G03;HMS2401A17;NSC30092;2-Hydroxyphenoxyacetic acid, 98+%;EINECS 228-684-8;MFCD00015454;NSC 30092;NSC-30092;STK674708;AKOS001042972;AT23402;SMR000102389;CS-0218081;EU-0033814;FT-0612631;EN300-00063;SR-01000391888;SR-01000391888-1;Z56869464;F0451-0561

Chemical Property of 2-(2-Hydroxyphenoxy)acetic acid

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 3.52E-05mmHg at 25°C
• Melting Point: 138-141 °C
• Refractive Index: 1.581
• Boiling Point: 339.6 °C at 760 mmHg
• Flash Point: 143 °C
• PSA: 66.76000
• Density: 1.367 g/cm³
• LogP: 0.85560
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 168.04225873
• Heavy Atom Count: 12
• Complexity: 157

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Hydroxyphenoxy)aceticacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)O)OCC(=O)O

Technology Process of 2-(2-Hydroxyphenoxy)acetic acid

There total 11 articles about 2-(2-Hydroxyphenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

ethyl 2-(2-hydroxyphenoxy)acetate (99186-63-7) → 2-(2-hydroxyphenoxy)acetic acid (6324-11-4)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + chloroacetic acid (79-11-8) → 2-(2-hydroxyphenoxy)acetic acid (6324-11-4) + 2-[2-(2-hydroxy-2-oxoethoxy)phenoxy]acetic acid (5411-14-3)

Guidance literature:

With alkali;

Reference yield:

→ 2-(2-hydroxyphenoxy)acetic acid (6324-11-4)

Guidance literature:

With alkaline solution; at 160 - 170 ℃;

upstream raw materials:

benzene-1,2-diol

chloroacetic acid

pyrocatechol monosodium salt

ethyl bromoacetate

Downstream raw materials:

2-(methoxycarbonyl)methoxyphenol

1,4-benzodioxan-2-one

(2-acetoxy-phenoxy)-acetic acid

(2-hydroxy-phenoxy)-acetic acid o-toluidide

Refernces

• 1、 Sampson, Peter,Crook, Michelle,Piorko, Adam. "1,4-Benzodioxin-2(3H)-one and Some of its Derivatives". . p. 1011 - 1016. Retrieved 2007/10/02.