Bismuth-212

Base Information

• Chemical Name: Bismuth-212
• CAS No.: 14913-49-6
• Molecular Formula: Bi
• Molecular Weight: 212
• Mol file: 14913-49-6.mol

Synonyms:212Bi radioisotope;Bi-212 radioisotope;Bismuth-212

Chemical Property of Bismuth-212

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 211.99129
• Heavy Atom Count: 1
• Complexity: 0

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [Bi]
• Isomeric SMILES: [212Bi]

Refernces

Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapy

10.1021/jm070401q

The study focuses on developing a novel bifunctional ligand, C-NETA, for use in radioimmunotherapy (RIT) to treat cancer. C-NETA is designed to efficiently bind cytotoxic metals like 212Bi, 213Bi, and 177Lu while being attached to a tumor-specific antibody, enhancing the efficacy of cancer therapy. The researchers synthesized C-NETA using a practical, reproducible, and scalable route. They evaluated its complexation kinetics with Bi(III) and Lu(III) using a UV spectroscopic Arsenazo III assay, finding that C-NETA forms complexes much faster than the commonly used C-DOTA ligand. The in vitro and in vivo stability of C-NETA radiolabeled with 205/6Bi and 177Lu was assessed, with results showing excellent stability in human serum and low organ uptake, particularly for 177Lu-C-NETA. The study concludes that C-NETA holds great promise for RIT due to its rapid complexation kinetics and high stability, and its design allows for further modifications to explore its potential in biomedical applications with other metals.