Synerazol

Base Information Edit

Chemical Name:Synerazol
CAS No.:127941-81-5
Molecular Formula:C22H23 N O7
Molecular Weight:413.4205
Hs Code.:
Mol file:127941-81-5.mol

Synonyms:synerazol

Suppliers and Price of Synerazol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
SYNERAZOL 95.00%
5MG
$ 497.31

Total 0 raw suppliers

Chemical Property of Synerazol Edit

Chemical Property:

Vapor Pressure:1.09E-19mmHg at 25°C
Boiling Point:684.8°Cat760mmHg
Flash Point:367.9°C
PSA：117.95000
Density:1.38g/cm³
LogP:1.32430
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:413.14745207
Heavy Atom Count:30
Complexity:827

Purity/Quality:: SYNERAZOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC=CC1C(O1)C2=C(C(=O)C3(O2)C(C(NC3=O)(C(=O)C4=CC=CC=C4)OC)O)C
Isomeric SMILES:CC/C=C/C1C(O1)C2=C(C(=O)C3(O2)C(C(NC3=O)(C(=O)C4=CC=CC=C4)OC)O)C

Technology Process of Synerazol

There total 17 articles about Synerazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 860020-01-5
(5S,8S,9R)-8-benzoyl-2-((1S,2R)-(Z)-1,2-epoxy-hex-3-enyl)-8-methoxy-3-methyl-9-trimethylsilyloxy-1-oxa-7-azaspirop[4.4]non-2-ene-4,6-dione

: 127941-81-5
(+)-synerazol

Guidance literature:: With ammonium fluoride; In methanol; at 0 ℃; for 0.25h;
DOI:10.1021/jo050664x

Reference yield: 55.0%

: 859216-28-7
(5S,8S,9R)-8-benzoyl-2-((1S,2R)-(Z)-1,2-epoxyhex-3-enyl)-8-methoxy-3-methyl-9-triisopropylsiloxy-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione

: 127941-81-5
(+)-synerazol

Guidance literature:: With ammonium fluoride; In methanol; at 0 - 20 ℃; for 12h;
DOI:10.1021/jo050664x

Reference yield:

: 859216-17-4
(2S,3R)-(Z)-2,3-epoxy-hept-4-enal

: 127941-81-5
(+)-synerazol

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA; HMPA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 32 percent / tetrahydrofuran; hexane / 1 h / -78 - -50 °C

2.1: 52 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.05 h / 20 °C

3.1: 65 percent / molecular sieves 3 Angstroem; dimethyl dioxirane / acetone / 4 h / -60 °C

4.1: 90 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂; H₂O / 0 - 20 °C

5.1: 95 percent / NH₄F / methanol / 0.25 h / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium fluoride; 3 A molecular sieve; 3,3-dimethyldioxirane; sodium hydrogencarbonate; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone;
DOI:10.1021/jo050664x