10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid

Base Information

• Chemical Name: 10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid
• CAS No.: 63141-67-3
• Molecular Formula: C₂₂H₂₃NO₂
• Molecular Weight: 333.43
• DSSTox Substance ID: DTXSID40212488
• Nikkaji Number: J395.486B
• ChEMBL ID: CHEMBL1196743
• Mol file: 63141-67-3.mol

Synonyms:10,11-dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid;MK 711;MK-711

Chemical Property of 10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.7E-11mmHg at 25°C
• Boiling Point: 516.5°C at 760 mmHg
• Flash Point: 266.2°C
• PSA: 40.54000
• Density: 1.204g/cm³
• LogP: 3.94880
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 333.172878976
• Heavy Atom Count: 25
• Complexity: 530

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(=C2C3=CC=CC=C3CCC4=C2C=C(C=C4)C(=O)O)CC1

Technology Process of 10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid

There total 2 articles about 10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

copper(l) cyanide + 1-methyl-4-(3-bromo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine (59895-04-4) → 1-methyl-4-(3-cyano-10,11-dihydro-5H-dibenzocyclohepten-5-ylidene)piperidine (59895-06-6) + 1-methyl-4-(3-carboxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine (63141-67-3)

Guidance literature:

In N-methyl-acetamide; chloroform; water; benzene;

Reference yield:

→ 1-methyl-4-(3-carboxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine (63141-67-3)

Guidance literature:

3-Cyanderivat E-1B, 6n HCl;

upstream raw materials:

1-methyl-4-(3-bromo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine