11α-Acetoxy-3β,14β-dihydroxy-12β-[(3-methyl-1-oxobutyl)oxy]pregn-5-en-20-one

Base Information

• Chemical Name: 11α-Acetoxy-3β,14β-dihydroxy-12β-[(3-methyl-1-oxobutyl)oxy]pregn-5-en-20-one
• CAS No.: 10163-83-4
• Molecular Formula: C₂₈H₄₂O₇
• Molecular Weight: 490.637
• Mol file: 10163-83-4.mol

Synonyms:14b-Pregn-5-en-20-one, 3b,11a,12b,14-tetrahydroxy-, 11-acetate 12-isovalerate (7CI,8CI); Drevogenin A(6CI); Isovaleric acid, 12-ester with 3b,11a,12b,14-tetrahydroxy-14b-pregn-5-en-20-one 11-acetate

Chemical Property of 11α-Acetoxy-3β,14β-dihydroxy-12β-[(3-methyl-1-oxobutyl)oxy]pregn-5-en-20-one

Chemical Property:

• Vapor Pressure: 3.31E-16mmHg at 25°C
• Boiling Point: 586.6°Cat760mmHg
• PKA: 13.36±0.70(Predicted)
• Flash Point: 185.2°C
• PSA: 110.13000
• Density: 1.2g/cm³
• LogP: 3.73960

Purity/Quality:

98%,99%, ^*data from raw suppliers

DrevogeninA 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): A poison.
• Hazard Codes: A poison.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11α-Acetoxy-3β,14β-dihydroxy-12β-[(3-methyl-1-oxobutyl)oxy]pregn-5-en-20-one

There total 7 articles about 11α-Acetoxy-3β,14β-dihydroxy-12β-[(3-methyl-1-oxobutyl)oxy]pregn-5-en-20-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dregeoside Aa1 (20230-40-4,20230-41-5) → D-cymarose (492-34-2,492-35-3,530-01-8,45876-76-4,87037-59-0,87037-60-3,89253-98-5,89253-99-6,99436-74-5,99437-07-7,135502-90-8,492-36-4) + asclepobiose (19939-78-7) + drevogenin A (10163-83-4)

Guidance literature:

With sulfuric acid; In methanol; at 50 ℃; for 0.5h;

DOI:10.1248/cpb.31.3971

Reference yield:

dregeoside Ap1 (89020-09-7) → D-cymarose (492-34-2,492-35-3,530-01-8,45876-76-4,87037-59-0,87037-60-3,89253-98-5,89253-99-6,99436-74-5,99437-07-7,135502-90-8,492-36-4) + O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-(1→4)-O-D-oleandropyranose (19939-78-7) + drevogenin A (10163-83-4)

Guidance literature:

With sulfuric acid; In methanol; at 50 ℃; for 0.5h;

DOI:10.1248/cpb.31.3971

Reference yield:

dregeoside A11 (89020-11-1) → D-cymarose (492-34-2,492-35-3,530-01-8,45876-76-4,87037-59-0,87037-60-3,89253-98-5,89253-99-6,99436-74-5,99437-07-7,135502-90-8,492-36-4) + drevogenin A (10163-83-4) + dregeoside Aa1 (20230-40-4,20230-41-5)

Guidance literature:

With sulfuric acid; In methanol; at 50 ℃; for 0.25h;

DOI:10.1248/cpb.31.3971

upstream raw materials:

dregeoside A_a1

dregeoside A_p1

dregeoside A₁₁

dregeoside A₀₁

Downstream raw materials:

drevogenin P

Refernces

• 1、 Bhatnagar,Stoecklin,Reichstein. "The pregnane derivatives of the seeds from Dregea abyssinica (Hochst.) K. Schum. (Asclepiadacea). II. Structure determination". . p. 133 - 147. Retrieved 2007/10/12.