9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine

Base Information

Chemical Name:9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine
CAS No.:150863-85-7
Molecular Formula:C₁₁H₁₂FIN₄O₄
Molecular Weight:410.144
Hs Code.:
Mol file:150863-85-7.mol

Synonyms:9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine

Suppliers and Price of 9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine

Chemical Property:

Vapor Pressure:9.08E-19mmHg at 25°C
Boiling Point:668.2°Cat760mmHg
Flash Point:357.9°C
PSA：102.52000
Density:2.32g/cm³
LogP:0.02820

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine

There total 8 articles about 9-(2-deoxy-2-fluororibofuranosyl)-2-iodo-6-methoxypurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 157762-24-8
2-iodo-6-methoxy-9-(2-deoxy-2-fluoro-3,5-di-O-(tetrahydro-2-pyranyl)-β-D-ribofuranosyl)purine

: 150863-85-7
2-iodo-6-methoxy-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 50 ℃; for 6h;
DOI:10.1080/15257779408012146

Reference yield:

: 114763-45-0
2-iodo-6-methoxy-9-(β-D-ribofuranosyl)purine

: 150863-85-7
2-iodo-6-methoxy-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 92 percent / DMAP, Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 74 percent / dimethylformamide / 48 h / 65 °C

4: 69 percent / acetic acid, Bu₄NF / tetrahydrofuran / 0.17 h / 0 °C

5: 96 percent / p-TsOH / dimethylformamide / 3 h / 0 °C

6: 90 percent / NH₃ / methanol / 4 h / 0 °C

7: 44 percent / DAST / CH₂Cl₂; pyridine / 3 h / Heating

8: 73 percent / PPTS / ethanol / 6 h / 50 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; ammonia; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; acetic acid; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408012146

Reference yield:

: 157762-22-6
2-iodo-6-methoxy-9-(2-O-acetyl-β-D-arabinofuranosyl)purine

: 150863-85-7
2-iodo-6-methoxy-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / p-TsOH / dimethylformamide / 3 h / 0 °C

2: 90 percent / NH₃ / methanol / 4 h / 0 °C

3: 44 percent / DAST / CH₂Cl₂; pyridine / 3 h / Heating

4: 73 percent / PPTS / ethanol / 6 h / 50 °C

With ammonia; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; In pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408012146