Phthaloyl-L-Leucine

Base Information

• Chemical Name: Phthaloyl-L-Leucine
• CAS No.: 2419-38-7
• Molecular Formula: C14H15NO4
• Molecular Weight: 261.277
• Hs Code.: 2925190090
• European Community (EC) Number: 219-337-1
• Nikkaji Number: J1.249.302I
• Mol file: 2419-38-7.mol

Synonyms:Phthaloyl-L-Leucine;29588-87-2;2419-38-7;(2r)-2-(1,3-dioxo-2,3-dihydro-1h-isoindol-2-yl)-4-methylpentanoic acid;(2R)-2-(1,3-dioxoisoindol-2-yl)-4-methylpentanoic acid;D-phthleucine;Pht-L-Leu-OH;(2S)-2-(1,3-dioxoisoindol-2-yl)-4-methylpentanoic acid;SCHEMBL11616001;AKOS015969569;FD21886;AS-49233;CS-0061017;EN300-238971

Chemical Property of Phthaloyl-L-Leucine

Chemical Property:

• Vapor Pressure: 4.95E-08mmHg at 25°C
• Boiling Point: 426.4 °C at 760 mmHg
• Flash Point: 211.7 °C
• PSA: 74.68000
• Density: 1.311 g/cm³
• LogP: 1.71980
• Storage Temp.: Store at RT.
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 261.10010796
• Heavy Atom Count: 19
• Complexity: 380

Purity/Quality:

95% ^*data from raw suppliers

Phthaloyl-L-Leucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)N1C(=O)C2=CC=CC=C2C1=O
• Isomeric SMILES: CC(C)C[C@H](C(=O)O)N1C(=O)C2=CC=CC=C2C1=O

Technology Process of Phthaloyl-L-Leucine

There total 11 articles about Phthaloyl-L-Leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + N-ethoxycarbonylphthalimide (22509-74-6) → N-phthaloyl-(S)-leucine (2419-38-7)

Guidance literature:

With sodium carbonate; In water; at 20 ℃; for 2h;

Reference yield: 99.0%

phthalic anhydride (85-44-9) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → N-phthaloyl-(S)-leucine (2419-38-7)

Guidance literature:

With triethylamine; In toluene; for 3h; Reflux;

Reference yield: 99.0%

N-tert-butoxycarbonyl-N-(quinolin-8-yl) Nα-phthaloyl-1-leucinamide (1228349-26-5) → tert-butyl (quinolin-8-yl)carbamate (137469-85-3) + N-phthaloyl-(S)-leucine (2419-38-7)

Guidance literature:

N-tert-butoxycarbonyl-N-(quinolin-8-yl) Nα-phthaloyl-1-leucinamide; With lithium hydroxide monohydrate; water; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 2.5h;

With hydrogenchloride; In water; pH=2;

DOI:10.1071/CH10033

upstream raw materials:

phthalic anhydride

L-leucine

N-(1-carboxy-3-methyl-butyl)-phthalamic acid

N-ethoxycarbonylphthalimide

Downstream raw materials:

N-(o-carboxybenzoyl)-L-leucine

L-leucine

benzene-1,2-dicarboxylic acid

(S)-3-amino-5-methylhexanoic acid