(4-amino-2-methylpyrimidin-5-yl)methyl trihydrogen diphosphate

Base Information

• Chemical Name: (4-amino-2-methylpyrimidin-5-yl)methyl trihydrogen diphosphate
• CAS No.: 841-01-0
• Molecular Formula: C6H11N3O7P2
• Molecular Weight: 299.115
• Mol file: 841-01-0.mol

Synonyms:

Chemical Property of (4-amino-2-methylpyrimidin-5-yl)methyl trihydrogen diphosphate

Chemical Property:

• Vapor Pressure: 3.31E-15mmHg at 25°C
• Boiling Point: 599.2°Cat760mmHg
• Flash Point: 316.2°C
• Density: 1.82g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-amino-2-methylpyrimidin-5-yl)methyl trihydrogen diphosphate

There total 1 articles about (4-amino-2-methylpyrimidin-5-yl)methyl trihydrogen diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-amino-5-hydroxymethylpyrimidine (73-67-6) → 4-amino-5-(hydroxymethyl)-2-methylpyrimidine pyrophosphate (841-01-0)

Guidance literature:

With Tris buffer; tris-(2-carboxyethyl)-phosphine hydrochloride; ATP; magnesium chloride; at 20 ℃; pH=7.5;

DOI:10.1021/ja0679634

Reference yield:

C7H10NO6PS + 4-amino-5-(hydroxymethyl)-2-methylpyrimidine pyrophosphate (841-01-0) → 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate (10023-48-0)

Guidance literature:

With thiamin phosphate synthase; at 20 ℃; for 2h; Enzymatic reaction;

Reference yield:

4-methyl-5-(β-hydroxyethyl)thiazole phosphate (3269-79-2) + 4-amino-5-(hydroxymethyl)-2-methylpyrimidine pyrophosphate (841-01-0) → 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate (10023-48-0)

Guidance literature:

With Tris-Cl; tris-(2-carboxyethyl)-phosphine hydrochloride; thiamin phosphate synthase; at 20 ℃; pH=7.6; Kinetics;

DOI:10.1021/ja0679634

upstream raw materials:

2-methyl-4-amino-5-hydroxymethylpyrimidine

Downstream raw materials:

2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl dihydrogen phosphate

Refernces