1H-Pyrrol-1-amine,2,5-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrrol-1-amine,2,5-dimethyl-(9CI)
• CAS No.: 765-71-9
• Molecular Formula: C6H10 N2
• Molecular Weight: 110.16
• Mol file: 765-71-9.mol

Synonyms:Pyrrole,1-amino-2,5-dimethyl- (7CI,8CI); (2,5-Dimethyl-1H-pyrrol-1-yl)amine;1-Amino-2,5-dimethylpyrrole; N-Amino-2,5-dimethylpyrrole

Chemical Property of 1H-Pyrrol-1-amine,2,5-dimethyl-(9CI)

Chemical Property:

• Vapor Pressure: 0.101mmHg at 25°C
• Boiling Point: 222.5°C at 760 mmHg
• Flash Point: 88.3°C
• PSA: 30.95000
• Density: 1.03g/cm³
• LogP: 1.39990

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrol-1-amine,2,5-dimethyl-(9CI)

There total 9 articles about 1H-Pyrrol-1-amine,2,5-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

hexa-1,5-diyne (628-16-0) → 2,5-dimethyl-1H-pyrrol-1-amine (765-71-9)

Guidance literature:

With C₂₄H₂₀B^(1-)*C₂₇H₃₉AuClN*K⁽¹⁺⁾; hydrazine; at 90 ℃; for 14h; sealed tube; Inert atmosphere;

DOI:10.1002/anie.201100740

Reference yield: 81.0%

2,5-dimethyl-1-<<<<2-(trimethylsilyl)ethyl>oxy>carbonyl>amino>pyrrole → 2,5-dimethyl-1H-pyrrol-1-amine (765-71-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jo9518260

Reference yield: 80.0%

benzyl (2,5-dimethyl-1H-pyrrol-1-yl)carbamate (101938-64-1) → 2,5-dimethyl-1H-pyrrol-1-amine (765-71-9)

Guidance literature:

With palladium on activated carbon; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr; Sealed tube;

DOI:10.1002/anie.202015654

upstream raw materials:

1-Formamino-2,5-dimethyl-pyrrol

benzyl (2,5-dimethyl-1H-pyrrol-1-yl)carbamate

2,5-hexanedione

hexa-1,5-diyne

Downstream raw materials:

N-(2,5-dimethyl-1H-pyrrol-1-yl)benzamide

Refernces

• 1、 Kinjo, Rei,Donnadieu, Bruno,Bertrand, Guy. "Gold-catalyzed hydroamination of alkynes and allenes with parent hydrazine". supporting information; experimental part. p. 5560 - 5563. Retrieved 2011/07/30.
• 2、 -. "1-aminoacetamidopyrroles and 1-aminoacetamido-2-(substituted)pyrroles and related compounds". . . Retrieved 2008/06/13.