4-Chloro-2,5-diethoxyaniline

Base Information

• Chemical Name: 4-Chloro-2,5-diethoxyaniline
• CAS No.: 35271-60-4
• Molecular Formula: C10H14 Cl N O2
• Molecular Weight: 215.68
• Hs Code.: 2922299090
• European Community (EC) Number: 252-476-6
• DSSTox Substance ID: DTXSID20188758
• Nikkaji Number: J289.955H
• Wikidata: Q83060599
• Mol file: 35271-60-4.mol

Synonyms:4-Chloro-2,5-diethoxyaniline;35271-60-4;EINECS 252-476-6;DTXSID20188758

Chemical Property of 4-Chloro-2,5-diethoxyaniline

Chemical Property:

• Vapor Pressure: 0.000112mmHg at 25°C
• Boiling Point: 336.5°Cat760mmHg
• Flash Point: 157.3°C
• PSA: 44.48000
• Density: 1.167g/cm³
• LogP: 3.30080
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 215.0713064
• Heavy Atom Count: 14
• Complexity: 168

Purity/Quality:

98%Min ^*data from raw suppliers

4-CHLORO-2,5-DIETHOXYANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1N)OCC)Cl

Technology Process of 4-Chloro-2,5-diethoxyaniline

There total 4 articles about 4-Chloro-2,5-diethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-chloro-2,5-diethoxy-4-nitrobenzene (91-43-0) → 4-chloro-2,5-diethoxyaniline (35271-60-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2010.11.003

Reference yield:

2-chloro-1,4-diethoxybenzene (52196-74-4) → 4-chloro-2,5-diethoxyaniline (35271-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; aqueous HNO₃

2: SnCl₂; concentrated aqueous HCl

With hydrogenchloride; nitric acid; acetic acid; tin(ll) chloride;

Reference yield:

chloro-p-hydroquinone (615-67-8) → 4-chloro-2,5-diethoxyaniline (35271-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 48 h / Reflux

2: HNO₃-SiO₂ / dichloromethane / Sonication

3: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

With HNO₃-SiO₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; acetone;

DOI:10.1016/j.ejmech.2010.11.003

upstream raw materials:

1-chloro-2,5-diethoxy-4-nitrobenzene

2-chloro-1,4-diethoxybenzene

chloro-p-hydroquinone

Downstream raw materials:

1-chloro-2,5-diethoxy-4-isothiocyanatobenzene

1-(4-chloro-2,5-diethoxyphenyl)-3-(3-propoxypropyl)thiourea

1-(4-chloro-2,5-diethoxyphenyl)-3-hexylthiourea

1-(4-chloro-2,5-diethoxyphenyl)-3-heptylthiourea

Refernces