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(1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol

Base Information Edit
  • Chemical Name:(1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol
  • CAS No.:50392-32-0
  • Molecular Formula:C27H46 O3
  • Molecular Weight:418.66
  • Hs Code.:
  • Mol file:50392-32-0.mol
(1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol

Synonyms:1a,25-Dihydroxycholesterol; Ro21-3245

Suppliers and Price of (1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
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Total 1 raw suppliers
Chemical Property of (1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol Edit
Chemical Property:
  • Vapor Pressure:2.99E-14mmHg at 25°C 
  • Boiling Point:547.1°C at 760 mmHg 
  • Flash Point:229.8°C 
  • PSA:60.69000 
  • Density:1.08g/cm3 
  • LogP:5.47440 
Purity/Quality:

99%min *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
Technology Process of (1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol

There total 2 articles about (1S,3R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 7 steps
1: 42.6 percent / DDQ / dioxane / 3.5 h / Heating
2: 82.7 percent / p-TsOH / benzene / 3 h / Ambient temperature
3: 69.8 percent / 10percent NaOH/MeOH, 30percent aq. H2O2 / methanol / 4 h / Ambient temperature
4: 1.) Li; 2.) Li/NH4Cl / 1.) NH3(l), Et2O, -33 deg C, 15 min; 2.) NH3(l), Et2O, -33 deg C, 30 min
5: 82 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 48 h / Ambient temperature
6: 88.7 percent / AcOH/H2O / 1 h / 80 °C
7: 94 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
With methanol; dmap; sodium hydroxide; lithium aluminium tetrahydride; water; dihydrogen peroxide; lithium; ammonium chloride; toluene-4-sulfonic acid; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; benzene;
DOI:10.1002/hlca.19810640621
Guidance literature:
Multi-step reaction with 4 steps
1: Py
2: (i) 1,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione, hexane, (ii) P(OMe)3, xylene
3: aq. KOH / methanol; benzene
4: (i) EtOH, (UV-irradiation), (ii) (heating)
With pyridine; potassium hydroxide; In methanol; benzene;
DOI:10.1248/cpb.26.2933
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