9,11-epoxycholest-7-ene-3,5,6-triol

Base Information

• Chemical Name: 9,11-epoxycholest-7-ene-3,5,6-triol
• CAS No.: 120152-00-3
• Molecular Formula: C₂₇H₄₄O₄
• Molecular Weight: 432.644
• Mol file: 120152-00-3.mol

Synonyms:9,11-Epoxy-9H-cyclopenta[a]phenanthrene,cholest-7-ene-3,5,6-triol deriv.; 9a,11a-Epoxycholest-7-ene-3b,5a,6b-triol

Chemical Property of 9,11-epoxycholest-7-ene-3,5,6-triol

Chemical Property:

• Vapor Pressure: 1.1E-14mmHg at 25°C
• Boiling Point: 556.1°Cat760mmHg
• Flash Point: 290.1°C
• PSA: 73.22000
• Density: 1.15g/cm³
• LogP: 4.60570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9,11-epoxycholest-7-ene-3,5,6-triol

There total 6 articles about 9,11-epoxycholest-7-ene-3,5,6-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9α,11α-epoxy-5-hydroxy-5α-cholest-7-en-3β,6β-diol 3,6-diacetate (463932-03-8) → 9α,11α-epoxy-5α-cholest-7-en-3β,5,6β-triol (120152-00-3)

Guidance literature:

With potassium carbonate; In methanol; at 25 ℃; for 6h;

DOI:10.1016/S0039-128X(02)00017-X

Reference yield:

5α,6β-dihydroxy-5α-cholest-7-en-3β-yl acetate (2551-04-4) → 9α,11α-epoxy-5α-cholest-7-en-3β,5,6β-triol (120152-00-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 378 mg / pyridine / 25 °C

2: 45 percent / Hg(OAc)2 / acetic acid; CHCl₃ / 24 h / 25 °C

3: 75 percent / mCPBA / CHCl₃ / 6 h / 0 °C

4: aq. K₂CO₃ / methanol / 6 h / 25 °C

With pyridine; mercury(II) diacetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; acetic acid;

DOI:10.1016/S0039-128X(02)00017-X

Reference yield:

5-hydroxy-5α-cholest-7-en-3β,6β-diol 3,6-diacetate (2551-05-5) → 9α,11α-epoxy-5α-cholest-7-en-3β,5,6β-triol (120152-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / Hg(OAc)2 / acetic acid; CHCl₃ / 24 h / 25 °C

2: 75 percent / mCPBA / CHCl₃ / 6 h / 0 °C

3: aq. K₂CO₃ / methanol / 6 h / 25 °C

With mercury(II) diacetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; chloroform; acetic acid;

DOI:10.1016/S0039-128X(02)00017-X

upstream raw materials:

9α,11α-epoxy-3β,5-dihydroxy-5α-cholest-7-en-6-one

9α,11α-epoxy-5-hydroxy-5α-cholest-7-en-3β,6β-diol 3,6-diacetate

5α,6β-dihydroxy-5α-cholest-7-en-3β-yl acetate

5-hydroxy-5α-cholest-7-en-3β,6β-diol 3,6-diacetate