1-pentofuranosyl-1H-imidazo[4,5-d]pyridazin-7-amine

Base Information

Chemical Name:1-pentofuranosyl-1H-imidazo[4,5-d]pyridazin-7-amine
CAS No.:92574-85-1
Molecular Formula:C₁₀H₁₃N₅O₄
Molecular Weight:267.244
Hs Code.:

Synonyms:

Suppliers and Price of 1-pentofuranosyl-1H-imidazo[4,5-d]pyridazin-7-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-pentofuranosyl-1H-imidazo[4,5-d]pyridazin-7-amine

Chemical Property:

Vapor Pressure:3.82E-25mmHg at 25°C
Boiling Point:773°Cat760mmHg
Flash Point:421.3°C
Density:2.08g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-pentofuranosyl-1H-imidazo[4,5-d]pyridazin-7-amine

There total 8 articles about 1-pentofuranosyl-1H-imidazo[4,5-d]pyridazin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 92574-84-0
3-(β-D-ribofuranosyl)-4-methylthioimidazo<4,5-d>pyridazine

: 92574-85-1
3-(β-D-ribofuranosyl)-4-aminoimidazo<4,5-d>pyridazine

: 10310-25-5
4-aminoimidazo<4,5-d>pyridazine

Guidance literature:: With ammonia; at 150 ℃; for 4h; steel bomb;
DOI:10.1002/jhet.5570210243

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 92574-85-1
3-(β-D-ribofuranosyl)-4-aminoimidazo<4,5-d>pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / stannic chloride / 1,2-dichloro-ethane / 3 h / Ambient temperature

2: 1.) BCl₃; 2.) CH₃OH / 1.) CH₂Cl₂, -78 deg C, 2 h; 2.) -78 deg C, 2 h, room temp. 30 min.

3: 60 percent / phosphorus pentasulfide / pyridine; H₂O / 12 h / Heating

4: 1.) 1N NaOH; 2.) 1N NaOH / 1.) aq. ethanol, room temp., 2 h; 2.) room temp., 1 h.

5: 42 percent / NH₃ (l) / 4 h / 150 °C / steel bomb

With methanol; diphosphorus pentasulfide; sodium hydroxide; ammonia; boron trichloride; tin(IV) chloride; In pyridine; water; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570210243

Reference yield:

: 82137-50-6
5-<(benzyloxy)methyl>-1,5-dihydro-4H-imidazo<4,5-d>pyridazin-4-one

: 92574-85-1
3-(β-D-ribofuranosyl)-4-aminoimidazo<4,5-d>pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1: amonium sulfate / Heating

2: 40 percent / stannic chloride / 1,2-dichloro-ethane / 3 h / Ambient temperature

3: 1.) BCl₃; 2.) CH₃OH / 1.) CH₂Cl₂, -78 deg C, 2 h; 2.) -78 deg C, 2 h, room temp. 30 min.

4: 60 percent / phosphorus pentasulfide / pyridine; H₂O / 12 h / Heating

5: 1.) 1N NaOH; 2.) 1N NaOH / 1.) aq. ethanol, room temp., 2 h; 2.) room temp., 1 h.

6: 42 percent / NH₃ (l) / 4 h / 150 °C / steel bomb

With methanol; diphosphorus pentasulfide; ammonium sulfate; sodium hydroxide; ammonia; boron trichloride; tin(IV) chloride; In pyridine; water; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570210243