Acetic acid, (6-hydroxy-2-naphthalenyl)oxy-

Base Information

• Chemical Name: Acetic acid, (6-hydroxy-2-naphthalenyl)oxy-
• CAS No.: 10441-36-8
• Molecular Formula: C₁₂H₁₀O₄
• Molecular Weight: 218.209
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID90146466
• Nikkaji Number: J1.556.162I
• Wikidata: Q83011294
• Mol file: 10441-36-8.mol

Synonyms:10441-36-8;2-[(6-HYDROXY-2-NAPHTHALENYL)OXY]ACETIC ACID;ACETIC ACID, (6-HYDROXY-2-NAPHTHALENYL)OXY-;2-(6-hydroxynaphthalen-2-yl)oxyacetic acid;2-((6-Hydroxynaphthalen-2-yl)oxy)acetic acid;2-[(6-hydroxynaphthalen-2-yl)oxy]acetic acid;SCHEMBL9714119;DTXSID90146466;(6-Hydroxy-2-naphthalenyl)oxyacetic acid;FT-0669892

Chemical Property of Acetic acid, (6-hydroxy-2-naphthalenyl)oxy-

Chemical Property:

• Vapor Pressure: 3.38E-09mmHg at 25°C
• Boiling Point: 458.4°Cat760mmHg
• Flash Point: 184.7°C
• PSA: 66.76000
• Density: 1.388g/cm³
• LogP: 2.00880
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 218.05790880
• Heavy Atom Count: 16
• Complexity: 253

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[(6-Hydroxy-2-naphthalenyl)oxy]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=C2)OCC(=O)O)C=C1O
• Uses: 2-[(6-Hydroxy-2-naphthalenyl)oxy]acetic Acid is a reagent used in the preparation of antitumor agents against sarcoma.

Technology Process of Acetic acid, (6-hydroxy-2-naphthalenyl)oxy-

There total 3 articles about Acetic acid, (6-hydroxy-2-naphthalenyl)oxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-amino-[2]naphthyloxy)-acetic acid ethyl ester (857555-33-0) → (6-hydroxy-[2]naphthyloxy)-acetic acid (10441-36-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; anschliessendes Erhitzen mit wss. H₂SO₄;

Reference yield:

(6-nitro-[2]naphthyloxy)-acetic acid (861066-65-1) → (6-hydroxy-[2]naphthyloxy)-acetic acid (10441-36-8)

Guidance literature:

Multi-step reaction with 3 steps

2: Raney nickel; THF / Hydrogenation

3: NaNO₂; aqueous HCl / anschliessendes Erhitzen mit wss. H₂SO₄

With tetrahydrofuran; hydrogenchloride; nickel; sodium nitrite;

Reference yield:

(6-nitro-[2]naphthyloxy)-acetic acid ethyl ester (861066-63-9) → (6-hydroxy-[2]naphthyloxy)-acetic acid (10441-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; THF / Hydrogenation

2: NaNO₂; aqueous HCl / anschliessendes Erhitzen mit wss. H₂SO₄

With tetrahydrofuran; hydrogenchloride; nickel; sodium nitrite;

upstream raw materials:

(6-amino-[2]naphthyloxy)-acetic acid ethyl ester

(6-nitro-[2]naphthyloxy)-acetic acid

(6-nitro-[2]naphthyloxy)-acetic acid ethyl ester