Vitamin D

Base Information

• Chemical Name: Vitamin D
• CAS No.: 1406-16-2
• Molecular Formula: C27H44O
• Molecular Weight: 384.63766
• Mol file: 1406-16-2.mol

Synonyms:CCRIS 5813; Activated ergosterol

Chemical Property of Vitamin D

Chemical Property:

• PSA: 20.23000
• LogP: 7.61900

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: vitamin D acts as a keratinization regulator, helping to improve skin feel and firmness with repeated use. This vitamin is absorbed through the skin’s outer layers. Studies are indicating that vitamin D is an important factor in epidermal cell turnover. It is generally found in combination with vitamin A, as such a mixture appears to help epithelial growth and promote good skin pigmentation. Like vitamin A, vitamin D is a major constituent of many fish and vegetable oils.

Refernces

An allylic nucleophilic substitution reaction of 1 α-hydroxyvitamin D derivatives

10.1016/S0040-4039(00)85093-5

The research focuses on the chemical transformation of 5,6-trans-vitamin D conjugated triene system into that of isovitamin D under nucleophilic conditions. The study reports the first instance of this conversion, which involves a carbanionic intermediate produced by n-butyl-lithium. The reaction is characterized as a novel SN2' reaction where a trialkylsilyloxide anion is substituted by a 1-butyl anion. The purpose of the research was to explore the chemical and biological interest in the transformations of vitamin D derivatives, specifically the conversion of 5,6-e-vitamin D (2) into isovitamin D (3). The key chemicals used in this process include 1,2-dimethylbutyl-lithium (n-butyl-lithium), tetrahydrofuran (THF) as a solvent, and bis-m-butyldimethylsilyl (TBDMS) ether as a protecting group for the la-hydroxy group of vitamin D. The conclusion of the research is that the reaction constitutes a successful conversion of the 5,6-trans-vitamin D triene system into that of isovitamin D under nucleophilic conditions, involving the addition of butyl anion at C-1 to give a pentadienyl carbanion, followed by expulsion of the silyloxide. The study also notes that methyl-lithium reacts similarly and that further exploration of the reaction with other types of nucleophiles is underway.