2-(3-Methoxyphenyl)pyrazolo[1,5-A]quinoline

Base Information

Chemical Name:2-(3-Methoxyphenyl)pyrazolo[1,5-A]quinoline
CAS No.:94594-74-8
Molecular Formula:C₁₈H₁₄N₂O
Molecular Weight:274.322
Hs Code.:
UNII:ESS8E72WRG
DSSTox Substance ID:DTXSID50915413
Nikkaji Number:J66.501K
Wikidata:Q82886404

Synonyms:2-(3-METHOXYPHENYL)PYRAZOLO[1,5-A]QUINOLINE;94594-74-8;BRN 0660901;2-(3-Methoxyphenyl)pyrazolo(1,5-a)quinoline;Pyrazolo(1,5-a)quinoline, 2-(3-methoxyphenyl)-;Pyrazolo[1,5-a]quinoline, 2-(3-methoxyphenyl)-;ESS8E72WRG;DTXSID50915413

Suppliers and Price of 2-(3-Methoxyphenyl)pyrazolo[1,5-A]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-(3-Methoxyphenyl)pyrazolo[1,5-A]quinoline

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:274.110613074
Heavy Atom Count:21
Complexity:361

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=NN3C(=C2)C=CC4=CC=CC=C43

Technology Process of 2-(3-Methoxyphenyl)pyrazolo[1,5-A]quinoline

There total 10 articles about 2-(3-Methoxyphenyl)pyrazolo[1,5-A]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 60230-70-8
2-(m-Anisyl)-4,5-dihydro-pyrazolo<1,5-a>-chinolin

: 94594-74-8
2-(3-methoxyphenyl)pyrazolo<1,5-a>quinoline

Guidance literature:: With sulfur; In neat (no solvent); at 260 ℃; for 0.5h;

Reference yield:

: 612-41-9
2-nitrocinnamic acid

: 94594-74-8
2-(3-methoxyphenyl)pyrazolo<1,5-a>quinoline

Guidance literature:: Multi-step reaction with 8 steps

1: H₂, 1percent aq. NaOH / Pd/C / H₂O / Ambient temperature

2: 1.) NaNO₂, HCl

3: 1.) SnCl₂, conc. HCl; 2.) 2.5percent HCl / 1.) 15 h; 2.) reflux, 5 min

4: p.toluenesulfonic acid / benzene / Heating

5: Na / various solvent(s) / Heating

6: 70 percent / NaOH / ethanol / Heating

7: 55 percent / neat (no solvent) / Heating

8: 71 percent / sulfur / neat (no solvent) / 0.5 h / 260 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sodium; toluene-4-sulfonic acid; sulfur; tin(ll) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; water; benzene;

Reference yield:

: 60230-78-6
1-amino-3,4-dihydroquinoline-2(1H)-one

: 94594-74-8
2-(3-methoxyphenyl)pyrazolo<1,5-a>quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: p.toluenesulfonic acid / benzene / Heating

2: Na / various solvent(s) / Heating

3: 70 percent / NaOH / ethanol / Heating

4: 55 percent / neat (no solvent) / Heating

5: 71 percent / sulfur / neat (no solvent) / 0.5 h / 260 °C

With sodium hydroxide; sodium; toluene-4-sulfonic acid; sulfur; In ethanol; benzene;