2-(1-Naphthyl)cyclohexanone

Base Information

• Chemical Name: 2-(1-Naphthyl)cyclohexanone
• CAS No.: 22591-15-7
• Molecular Formula: C16H16 O
• Molecular Weight: 224.302
• NSC Number: 137151
• DSSTox Substance ID: DTXSID60300472
• Nikkaji Number: J836.564D
• ChEMBL ID: CHEMBL1449840
• Mol file: 22591-15-7.mol

Synonyms:2-(1-naphthyl)cyclohexanone;22591-15-7;2-naphthalen-1-ylcyclohexan-1-one;2-(Naphthalen-1-yl)cyclohexanone;NSC137151;MLS000703154;SCHEMBL4800917;CHEMBL1449840;DTXSID60300472;HMS2531C13;AKOS012096186;NSC-137151;SMR000224518;2-(NAPHTHALEN-1-YL)CYCLOHEXAN-1-ONE;AB-131/42301012

Chemical Property of 2-(1-Naphthyl)cyclohexanone

Chemical Property:

• Vapor Pressure: 1.76E-06mmHg at 25°C
• Boiling Point: 396°Cat760mmHg
• Flash Point: 174.9°C
• Density: 1.114g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 224.120115130
• Heavy Atom Count: 17
• Complexity: 283

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(=O)C(C1)C2=CC=CC3=CC=CC=C32

Technology Process of 2-(1-Naphthyl)cyclohexanone

There total 21 articles about 2-(1-Naphthyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(1-Naphthyl)-1-nitrocyclohexane → 2-(naphthalen-1-yl)cyclohexanone (22591-15-7)

Guidance literature:

2-(1-Naphthyl)-1-nitrocyclohexane; With sodium ethanolate; In ethanol; at 20 ℃; for 1h;

With hydrogenchloride; In ethanol; at 0 ℃;

Reference yield: 74.0%

1-(2-oxo-5-hexenyl)naphthalene (586961-58-2) → 2-(naphthalen-1-yl)cyclohexanone (22591-15-7)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); chloro-trimethyl-silane; copper dichloride; In 1,4-dioxane; at 70 ℃;

DOI:10.1021/ol034879+

Reference yield: 70.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + 1-Bromonaphthalene (90-11-9) → 2-(naphthalen-1-yl)cyclohexanone (22591-15-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; tributyltin fluoride; In benzene; at 20 - 60 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c0cc02492a

upstream raw materials:

1-naphthylmagnesiumbromide

2-Chlorocyclohexanone

rac-(-)-(1R,2S)-2-(naphthalen-1-yl)cyclohexan-1-ol

1-Bromonaphthalene

Downstream raw materials:

1-(2-methyl-cyclohex-1-enyl)-naphthalene

1-(1-Naphthyl)-2-phenethinylcyclohexen

benzo[b]naphtho[1,8-de]pyran

cis-2-(naphthalen-1-yl)cyclohexan-1-ol