(22R,24ξ)-Ergost-5-ene-3β,22,25,28-tetrol

Base Information

• Chemical Name: (22R,24ξ)-Ergost-5-ene-3β,22,25,28-tetrol
• CAS No.: 77517-54-5
• Molecular Formula: C₂₈H₄₈O₄
• Molecular Weight: 448.687
• Mol file: 77517-54-5.mol

Synonyms:(5R,6S)-6-((3S,8S,9S,10R,13S,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-3-hydroxymethyl-2-methyl-heptane-2,5-diol;

Chemical Property of (22R,24ξ)-Ergost-5-ene-3β,22,25,28-tetrol

Chemical Property:

• PSA: 80.92000
• LogP: 4.69280

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (22R,24ξ)-Ergost-5-ene-3β,22,25,28-tetrol

There total 2 articles about (22R,24ξ)-Ergost-5-ene-3β,22,25,28-tetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(22R,24ξ)-24-methylcholest-5-en-3β,22,25,28-tetraol-3,22,28-triacetate (80322-12-9) → depresosterol (77517-54-5)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88896-7

Reference yield:

(22R,24ξ,28ξ)-22,28-oxido-24-methylcholest-5-en-3β,25,28-triol-3,28-diacetate (77517-51-2) → depresosterol (77517-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.)NaBH₄; 2.) AcOH / 1.) MeOH, reflux, 2 h; 2.) pyridine

2: 7 mg / 0.5N KOH / methanol / 1 h / Ambient temperature

With potassium hydroxide; sodium tetrahydroborate; acetic acid; In methanol;

DOI:10.1016/S0040-4020(01)88896-7

upstream raw materials:

(22R,24ξ)-24-methylcholest-5-en-3β,22,25,28-tetraol-3,22,28-triacetate

(22R,24ξ,28ξ)-22,28-oxido-24-methylcholest-5-en-3β,25,28-triol-3,28-diacetate