3-Glycyl-2-methyl-4-thiazolidinecarboxylic acid hydrobromide

Base Information

• Chemical Name: 3-Glycyl-2-methyl-4-thiazolidinecarboxylic acid hydrobromide
• CAS No.: 107321-77-7
• Molecular Formula: BrH*C₇H₁₂N₂O₃S
• Molecular Weight: 285.162
• DSSTox Substance ID: DTXSID60910292
• Mol file: 107321-77-7.mol

Synonyms:107321-77-7;3-Glycyl-2-methyl-4-thiazolidinecarboxylic acid hydrobromide;4-Thiazolidinecarboxylic acid, 3-glycyl-2-methyl-, hydrobromide;2-Methyl-3-glycylthiazolidine-4-carboxylic acid hydrobromide;4-Thiazolidinecarboxylic acid, 3-(aminoacetyl)-2-methyl-, monohydrobromide;C7H12N2O3S.BrH;DTXSID60910292;C7-H12-N2-O3-S.Br-H;LS-151192;3-Glycyl-2-methyl-1,3-thiazolidine-4-carboxylic acid--hydrogen bromide (1/1)

Chemical Property of 3-Glycyl-2-methyl-4-thiazolidinecarboxylic acid hydrobromide

Chemical Property:

• Vapor Pressure: 6.01E-10mmHg at 25°C
• Boiling Point: 465.3°Cat760mmHg
• Flash Point: 235.2°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 283.98303
• Heavy Atom Count: 14
• Complexity: 234

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1N(C(CS1)C(=O)O)C(=O)CN.Br

Technology Process of 3-Glycyl-2-methyl-4-thiazolidinecarboxylic acid hydrobromide

There total 2 articles about 3-Glycyl-2-methyl-4-thiazolidinecarboxylic acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(R)-3-(2-Benzyloxycarbonylamino-acetyl)-2-methyl-thiazolidine-4-carboxylic acid (107321-69-7) → 2-methyl-3-glycylthiazolidine-4-carboxylic acid hydrobromide (107321-77-7)

Guidance literature:

With hydrogen bromide; Ambient temperature;

Reference yield:

(4R)-2-Methyl-1,3-thiazolidine-4-carboxylic acid (190062-99-8,7347-97-9,88855-01-0,88855-02-1,88855-03-2,88855-04-3) → 2-methyl-3-glycylthiazolidine-4-carboxylic acid hydrobromide (107321-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; isobutylchloroformate / 1.) THF, -15 deg C, 3 h; 2.) rt, 20-24 h

2: 75 percent / hydrogen bromide in acetic acid / Ambient temperature

With hydrogen bromide; triethylamine; isobutyl chloroformate;

upstream raw materials:

(R)-3-(2-Benzyloxycarbonylamino-acetyl)-2-methyl-thiazolidine-4-carboxylic acid

(4R)-2-Methyl-1,3-thiazolidine-4-carboxylic acid