1-Benzhydryl-4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride

Base Information

• Chemical Name: 1-Benzhydryl-4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride
• CAS No.: 104690-88-2
• Molecular Formula: C₂₉H₃₄N₂O₃*2ClH
• Molecular Weight: 531.522
• Mol file: 104690-88-2.mol

Synonyms:1-Benzhydryl-4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride;1-(Diphenylmethyl)-4-(3-(2,3,4-trimethoxyphenyl)-2-propenyl)piperazine dihydrochloride;Piperazine, 1-(diphenylmethyl)-4-(3-(2,3,4-trimethoxyphenyl)-2-propenyl)-, dihydrochloride;104690-88-2;LS-111885

Chemical Property of 1-Benzhydryl-4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride

Chemical Property:

• Vapor Pressure: 8.4E-14mmHg at 25°C
• Boiling Point: 587.9°Cat760mmHg
• Flash Point: 155.9°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 530.2102984
• Heavy Atom Count: 36
• Complexity: 576

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)C=CCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)OC)OC.Cl.Cl
• Isomeric SMILES: COC1=C(C(=C(C=C1)/C=C/CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)OC)OC.Cl.Cl

Technology Process of 1-Benzhydryl-4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride

There total 5 articles about 1-Benzhydryl-4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1-diphenylmethyl-4-(2,3,4-trimethoxycinnamoyl)piperazine hydrochloride (104690-79-1) → 1--4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride (104690-88-2)

Guidance literature:

With sodium hydroxide; lithium aluminium tetrahydride; 1.) AcOEt, water; 2.) Et₂O, room temp., 4 h;

DOI:10.1248/cpb.35.4124

Reference yield: 20.0%

→ 1--4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride (104690-88-2)

Guidance literature:

Reference yield:

diphenylmethylpiperazine (841-77-0) → 1--4-(2,3,4-trimethoxycinnamyl)piperazine dihydrochloride (104690-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) tert-BuOH-MeCN, 0 deg C, 0.5 h; 2.) tert-BuOH-MeCN, room temp., 1 h

2: 58 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h

With chloroformic acid ethyl ester; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene;

DOI:10.1248/cpb.35.4124

upstream raw materials:

1-diphenylmethyl-4-(2,3,4-trimethoxycinnamoyl)piperazine hydrochloride

diphenylmethylpiperazine

trans-2,3,4-trimethoxycinnamic acid

3-(2,3,4-trimethoxy-phenyl)-acryloyl chloride

Refernces

• 1、 -. "Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical compositions comprising said compounds as active ingredient for treating a cerebrovascular disease". . . Retrieved 2008/06/13.