2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol

Base Information

Chemical Name:2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol
CAS No.:56882-48-5
Molecular Formula:C18H16N2O3
Molecular Weight:308.3312
Hs Code.:
DSSTox Substance ID:DTXSID60972315
Nikkaji Number:J61.468H
ChEMBL ID:CHEMBL349985

Synonyms:BRN 0570259;56882-48-5;2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol;Imidazo(2,1-a)isoquinolin-5-ol, 2,3,5,6-tetrahydro-5-(1,3-benzodioxol-5-yl)-;CHEMBL349985;SCHEMBL9691840;DTXSID60972315;LS-77905;2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)imidazo[2,1-a]isoquinolin-5-ol;5-(2H-1,3-Benzodioxol-5-yl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Suppliers and Price of 2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,3,5,6-TETRAHYDRO-5-(1,3-BENZODIOXOL-5-YL)IMIDAZO[2,1-A]ISOQUINOLIN-5-OL 95.00%
5MG
$ 502.50

Total 3 raw suppliers

Chemical Property of 2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol

Chemical Property:

Vapor Pressure:1.6E-10mmHg at 25°C
Melting Point:176-178 °C(Solv: dichloromethane (75-09-2))
Boiling Point:492.7°Cat760mmHg
PKA:11.01±0.20(Predicted)
Flash Point:251.8°C
PSA：54.29000
Density:1.46g/cm³
LogP:1.25240
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:308.11609238
Heavy Atom Count:23
Complexity:511

Purity/Quality:

99% ^*data from raw suppliers

2,3,5,6-TETRAHYDRO-5-(1,3-BENZODIOXOL-5-YL)IMIDAZO[2,1-A]ISOQUINOLIN-5-OL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3CC2(C4=CC5=C(C=C4)OCO5)O

Technology Process of 2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol

There total 4 articles about 2,3,5,6-Tetrahydro-5-(1,3-benzodioxol-5-yl)-imidazo(2,1-a)isoquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94-53-1
Piperonylic acid

: 56882-48-5
5-(3,4-methylenedioxyphenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 5 h / Heating

2: benzene; methanol / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; thionyl chloride; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 25054-53-9
3,4-(methylenedioxy)benzoyl chloride

: 56882-48-5
5-(3,4-methylenedioxyphenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; methanol / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h

With n-butyllithium; In methanol; benzene;
DOI:10.1021/jm00359a025

Reference yield:

: 326-56-7
methyl 3,4-methylenedioxybenzoate

: 57327-93-2
2-(o-Tolyl)-2-imidazoline

: 56882-48-5
5-(3,4-methylenedioxyphenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h;
DOI:10.1021/jm00359a025