Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo-

Base Information

Chemical Name:Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo-
CAS No.:68689-69-0
Molecular Formula:C₂₅H₂₉N₅O₇
Molecular Weight:511.535
Hs Code.:
DSSTox Substance ID:DTXSID10988380

Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo-

Synonyms:BRN 5680608;68689-69-0;Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo-;DTXSID10988380;C25H29N5O7;C25-H29-N5-O7;LS-134080;2-(4-{2-[4-(2,3-Dihydroxypropoxy)phenyl]-2-oxoethyl}piperazin-1-yl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid

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Chemical Property of Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo-

Chemical Property:

Vapor Pressure:7.62E-27mmHg at 25°C
Boiling Point:797.7°Cat760mmHg
Flash Point:436.3°C
Density:1.404g/cm³
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:511.20669828
Heavy Atom Count:37
Complexity:854

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCN(CC3)CC(=O)C4=CC=C(C=C4)OCC(CO)O)C(=O)O

Technology Process of Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo-

There total 4 articles about Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-2-(4-(2-(4-(2,3-dihydroxypropoxy)phenyl)-2-oxoethyl)-1-piperazinyl)-8-ethyl-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2491-37-4
2-bromo-1-(3-hydroxyphenyl)ethanone

: 68689-69-0
acide <-4 piperazinyl-1>-2 ethyl-8 oxo-5 dihydro-5,8 pyrido <2,3-d> pyrimidine-6 carboxylique

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / triethylamine / CHCl₃ / 2 h / Heating

2: 48 percent / ethylate de sodium / ethanol / 6 h / Heating

3: Na₂CO₃

With sodium ethanolate; sodium carbonate; triethylamine; In ethanol; chloroform;

Reference yield:

: ethoxycarbonyl-6 ethyl-8 <(hydroxy-4 benzoylmethyl)-4 piperazinyl-1>-2 oxo-5 dihydro-5,8 pyrido <2,3-d> pyrimidine

: 68689-69-0
acide <-4 piperazinyl-1>-2 ethyl-8 oxo-5 dihydro-5,8 pyrido <2,3-d> pyrimidine-6 carboxylique

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / ethylate de sodium / ethanol / 6 h / Heating

2: Na₂CO₃

With sodium ethanolate; sodium carbonate; In ethanol;

Reference yield:

: 51940-43-3
ethyl 5,8-dihydro-8-ethyl-2-(1-piperazinyl)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate

: 68689-69-0
acide <-4 piperazinyl-1>-2 ethyl-8 oxo-5 dihydro-5,8 pyrido <2,3-d> pyrimidine-6 carboxylique

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / triethylamine / CHCl₃ / 2 h / Heating

2: 48 percent / ethylate de sodium / ethanol / 6 h / Heating

3: Na₂CO₃

With sodium ethanolate; sodium carbonate; triethylamine; In ethanol; chloroform;